Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
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DOI：
10.3390/molecules15063932
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发表时间：
2010-06-01
期刊：
影响因子：
4.6
通讯作者：
Al-Shihry, Shar S.
中科院分区：
文献类型：
--
作者：
Al-Taisan, Khulud M.;Al-Hazimi, Hassan M. A.;Al-Shihry, Shar S.
由2-氨基硫酚-3-羧酸酯及其碳腈类似物合成了几种2-未取代的硫代[2，3-d]嘧啶类化合物。利用微波和热辐射技术合成了具有代表性的三唑硫代嘧啶和2-硫代硫代嘧啶。通过红外光谱、核磁共振、二维核磁共振和质谱学数据对所合成化合物的结构进行了表征。并对部分合成化合物的生物活性进行了考察。
Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolothienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techniques. Structures of the prepared compounds were elucidated on the basis of IR, NMR, 2D NMR and mass spectral data. The biological activity of some selected synthesized compounds was also examined.