Search for a shared segment on chromosome 10q26 in patients with bipolar affective disorder or schizophrenia from the Faroe Islands
Search for a shared segment on chromosome 10q26 in patients with bipolar affective disorder or schizophrenia from the Faroe Islands
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DOI：
10.1002/ajmg.10148
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发表时间：
2002-03-08
期刊：
影响因子：
--
通讯作者：
Kruse, TA
中科院分区：
文献类型：
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作者：
Ewald, H;Flint, TJ;Kruse, TA
先前的连锁研究表明，双相情感障碍和精神分裂症的染色体10 q26上可能存在一个新的位点。我们寻找等位基因关联和染色体片段和单倍型共享染色体10 q26之间的远亲双相情感障碍或精神分裂症患者和控制从法罗群岛的相对孤立的人口调查22个微卫星标记从35厘米的区域。我们使用了一种结合了无假设检验和基于系谱关系的检验的方法。D10 S1230和D10 S2322之间的6.5 cM区域，在以前的连锁分析中已经暗示，得到了一些支持。对片段共享的搜索在双相情感障碍患者中产生了大约0.02的经验P值，在精神分裂症患者中产生了大约0.03的经验P值。对于这两种疾病，组合等位基因关联在标记D10 S1723处产生约0.003的经验P值。单倍型数据挖掘方法支持该地区的单倍型共享。在另一个，更远，11.5 cM的区域之间的标记D10 S214和D10 S505，这已经得到了支持，在以前的连锁研究，增加单倍型共享双相情感障碍患者的Fisher精确检验，测试的基础上系谱和单倍型数据挖掘支持。我们的研究结果为双相情感障碍和精神分裂症的风险基因提供了一些支持。(C)2002 Wiley-Liss，Inc.
Previous linkage studies have suggested a new locus for bipolar affective disorder and possibly also for schizophrenia on chromosome 10q26. We searched for allelic association and chromosome segment and haplotype sharing on chromosome 10q26 among distantly related patients with bipolar affective disorder or schizophrenia and controls from the relatively isolated population of the Faroe Islands by investigating 22 microsatellite markers from a 35 cM region. We used a combined approach with both assumption free tests and tests based on genealogical relationships. The 6.5 cM region between D10S1230 and D10S2322, which has been implied in previous linkage analyses, received some support. A search for segment sharing yielded empirical P-values around 0.02 among patients with bipolar affective disorder and around 0.03 for patients with schizophrenia. For both disorders combined allelic association yielded empirical P-values around 0.003 at marker D10S1723. A haplotype data mining approach supported haplotype sharing in this region. In another, more distal, 11.5 cM region between markers D10S214 and D10S505, which has received support in previous linkage studies, increased haplotype sharing in patients with bipolar affective disorder was supported by Fisher's exact test, tests based on genealogy and by haplotype data mining. Our findings yield some support for a risk gene for bipolar affective disorder and possibly also for schizophrenia. (C) 2002 Wiley-Liss, Inc.