PROPENSITY TO 'RELAPSE' FOLLOWING EXPOSURE TO COCAINE CUES IS ASSOCIATED WITH THE RECRUITMENT OF SPECIFIC THALAMIC AND EPITHALAMIC NUCLEI
PROPENSITY TO 'RELAPSE' FOLLOWING EXPOSURE TO COCAINE CUES IS ASSOCIATED WITH THE RECRUITMENT OF SPECIFIC THALAMIC AND EPITHALAMIC NUCLEI
复制标题
DOI：
10.1016/j.neuroscience.2011.09.047
复制
发表时间：
2011-12-29
期刊：
影响因子：
3.3
通讯作者：
Dayas, C. V.
中科院分区：
文献类型：
--
作者：
James, M. H.;Charnley, J. L.;Dayas, C. V.
丘脑被认为是腹侧纹状体和背侧纹状体之间的重要界面，因此可能有助于强迫性药物寻求行为。最近的证据表明，室旁丘脑（PVT），背中线丘脑核，和内侧背丘脑（MD）参与药物自我管理和响应药物相关的线索。然而，目前，这些丘脑区域在介导线索诱导的可卡因寻求恢复中的作用尚不清楚。同样，缰复合体，上丘脑的一部分，已被牵连在尼古丁自我管理和线索诱导恢复海洛因寻求，但可卡因复吸行为中的作用，这一地区很少受到关注。训练大鼠（n=20）在与药物可用性（S+）或药物不可用性（S-）相关的辨别性刺激存在下自我施用可卡因。一旦达到稳定的响应水平，杠杆按压就被熄灭。然后测试动物的恢复和处死后立即呈现的S-或S+的歧视性刺激，和Fos蛋白表达进行了评估，在丘脑和上丘脑区域。有趣的是，在恢复行为中观察到显著变化，允许在高恢复（HR）、低恢复（LR）和对照动物之间进行比较。与LR动物相比，HR动物在PVT、中间背丘脑和缰核的内侧和外侧分支中表现出Fos蛋白表达增加。我们的数据提供的证据表明，丘脑和上丘脑核的激活与恢复可卡因寻求药物相关的线索引起的倾向。我们还建立在现有的数据突出的重要性，PVT在恢复行为。皇冠版权所有（C）2011由爱思唯尔有限公司代表IBRO发布。All rights reserved.
The thalamus is considered an important interface between the ventral striatopallidum and the dorsal striatum, and may therefore contribute to compulsive drug-seeking behaviour. Recent evidence suggests that the paraventricular thalamus (PVT), a dorsal midline thalamic nucleus, and the mediodorsal thalamus (MD) are involved in drug self-administration and respond to drug-associated cues. At present, however, the role of these thalamic regions in mediating cue-induced reinstatement of cocaine-seeking is unclear. Similarly, the habenula complex, part of the epithalamus, has been implicated in nicotine self-administration and cue-induced reinstatement of heroin seeking, but the role of this region in cocaine reinstatement behaviour has received little attention. Rats (n=20) were trained to self-administer cocaine in the presence of discriminative stimuli associated with drug availability (S+) or drug non-availability (S-). Once a stable level of responding was reached, lever pressing was extinguished. Animals were then tested for reinstatement and sacrificed immediately following the presentation of either the S- or S+ discriminative stimuli, and Fos-protein expression was assessed in thalamic and epithalamic regions. Interestingly, significant variation was observed in reinstatement behaviour, allowing a comparison between high-reinstating (HR), low-reinstating (LR) and control animals. Compared with LR animals, HR animals exhibited increased Fos-protein expression in the PVT, intermediodorsal thalamus and the medial and lateral divisions of the habenula. Our data provide evidence that activation of thalamic and epithalamic nuclei is associated with propensity to reinstate to cocaine-seeking elicited by drug-related cues. We also build upon existing data highlighting the importance of the PVT in reinstatement behaviour. Crown Copyright (C) 2011 Published by Elsevier Ltd on behalf of IBRO. All rights reserved.