Bioionic Liquid Conjugation as Universal Approach To Engineer Hemostatic Bioadhesives
Bioionic Liquid Conjugation as Universal Approach To Engineer Hemostatic Bioadhesives
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DOI：
10.1021/acsami.9b08757
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发表时间：
2019-10-23
影响因子：
9.5
通讯作者：
Noshadi, Iman
中科院分区：
文献类型：
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作者：
Krishnadoss, Vaishali;Melillo, Atlee;Noshadi, Iman
粘附到潮湿和动态表面对于许多生物医学应用至关重要。然而，有效组织粘合剂的开发受到所需性能组合的挑战，所述性能组合包括与天然组织的机械相似性、对湿表面的高粘附性、止血性能、生物降解性、高生物相容性和易用性。在这项研究中，我们报告了一种新的生物启发设计与生物离子液体（BIL）共轭聚合物工程多功能高粘性，可生物降解，生物相容性和止血粘合剂。基于胆碱的BIL是细胞膜中磷脂双层的结构前体。我们表明，胆碱分子与天然衍生的聚合物（即，明胶）和合成聚合物（即，聚乙二醇）显著增加了它们的粘合强度和止血性能。合成或天然聚合物和BIL在室温下混合并通过可见光光聚合交联，以制备具有可调机械、物理、粘合和止血特性的水凝胶。与对照相比，水凝胶粘合剂在尾部切割和肝脏撕裂大鼠动物模型中显示出总血量损失减少接近50%。该粘合剂技术平台有望在从组织修复到伤口敷料和柔性电子产品的附着等领域具有更广泛的应用前景。
Adhesion to wet and dynamic surfaces is vital for many biomedical applications. However, the development of effective tissue adhesives has been challenged by the required combination of properties, which includes mechanical similarity to the native tissue, high adhesion to wet surfaces, hemostatic properties, biodegradability, high bio-compatibility, and ease of use. In this study, we report a novel bioinspired design with bioionic liquid (BIL) conjugated polymers to engineer multifunctional highly sticky, biodegradable, biocompatible, and hemostatic adhesives. Choline-based BIL is a structural precursor of the phospholipid bilayer in the cell membrane. We show that the conjugation of choline molecules to naturally derived polymers (i.e., gelatin) and synthetic polymers (i.e., polyethylene glycol) significantly increases their adhesive strength and hemostatic properties. Synthetic or natural polymers and BILs were mixed at room temperature and cross-linked via visible light photopolymerization to make hydrogels with tunable mechanical, physical, adhesive, and hemostatic properties. The hydrogel adhesive exhibits a close to 50% decrease in the total blood volume loss in tail cut and liver laceration rat animal models compared to the control. This technology platform for adhesives is expected to have further reaching application vistas from tissue repair to wound dressings and the attachment of flexible electronics.