Risk factors for intestinal metaplasia in a southeastern Chinese population: an analysis of 28,745 cases
Risk factors for intestinal metaplasia in a southeastern Chinese population: an analysis of 28,745 cases
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DOI：
10.1007/s00432-016-2299-9
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发表时间：
2017-03-01
影响因子：
3.6
通讯作者：
Xu, Shun-Fu
中科院分区：
文献类型：
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作者：
Jiang, Jian-Xia;Liu, Qing;Xu, Shun-Fu
目的：探讨中国东南部人群肠化生的危险因素。本研究纳入2008 - 2013年在南京医科大学第一附属医院行上消化道内镜检查和内镜活检的患者。分别分析各种人口统计学、地理、临床和病理数据，以确定肠化生的危险因素。17个地市的肠化生发病率差异有统计学意义（P < 0.01），范围为16.79% ~ 38.56%，与年龄40 ~ 70岁、男性、胃溃疡、胆汁反流、幽门螺杆菌感染、萎缩性胃炎、不典型增生、胃癌、慢性和急性炎症程度、人均国内生产总值呈正相关（P < 0.01）。多元线性回归分析显示，在所有因素中，只有人均国内生产总值显示出肠化生发生率的显著差异。本研究证实年龄、男性、胃溃疡、胆汁反流、幽门螺杆菌感染、慢性和急性炎症严重程度是肠化生的危险因素。我们推测不同地区的人均国内生产总值可能是影响肠化生发病率的潜在独立危险因素。
To identify risk factors for intestinal metaplasia in a southeastern Chinese population.Subjects who underwent upper GI endoscopy and endoscopic biopsy in the First Affiliated Hospital of Nanjing Medical University from 2008 to 2013 were included into this study. Various demographic, geographic, clinical and pathological data were analyzed separately to identify risk factors for intestinal metaplasia.The incidence of intestinal metaplasia differed significantly in 17 municipal areas ranging from 16.79 to 38.56% and was positively correlated with the age range of 40-70 years, male gender, gastric ulcer, bile reflux, Helicobacter pylori infection, atrophic gastritis, dysplasia, gastric cancer, degree of chronic and acute inflammation, and gross domestic product per capita (P < 0.01). Multivariate linear regression analysis indicated that only gross domestic product per capita revealed a significant difference in the incidence of intestinal metaplasia among all factors mentioned.This study confirms age, male gender, gastric ulcer, bile reflux, H. pylori infection, severe degree of chronic and acute inflammation to be the risk factors for intestinal metaplasia. We speculate that the gross domestic product per capita of different areas may be a potential independent risk factor impacting the incidence of intestinal metaplasia.