Association between periodontitis and chronic kidney disease by functional atherosclerosis status among older Japanese individuals: a cross‐sectional study
Association between periodontitis and chronic kidney disease by functional atherosclerosis status among older Japanese individuals: a cross‐sectional study
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日本老年人功能性动脉粥样硬化状态与牙周炎和慢性肾脏病之间的关联：一项横断面研究
DOI：
10.1111/jcpe.13755
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发表时间：
2022
影响因子：
6.7
通讯作者：
Takahiro Maeda
中科院分区：
文献类型：
--
作者：
Yuji Shimizu;Hirotomo Yamanashi;Masayasu Kitamura;Jun Miyata;Fumiaki Nonaka;Seiko Nakamichi;Toshiyuki Saito;Yasuhiro Nagata;Takahiro Maeda
本研究旨在阐明功能性动脉粥样硬化对牙周炎与慢性肾脏病之间关系的影响。材料与方法对参加口腔健康检查的998名60~99 年龄的日本老年人进行横断面研究。早期牙周炎定义为牙周袋深度4.0~5.9 mm，晚期牙周炎定义为≥6.0 mm。结果998例受试者中，238例(23.8%)存在慢性肾功能不全。在没有功能性动脉粥样硬化的参与者中，牙周炎和慢性肾脏病之间没有明显的关联。调整已知的心血管危险因素后，早期牙周炎的优势比(OR)为1.31(0.81~2.11)，晚期牙周炎的优势比(OR)为0.74(0.41~1.34)。与功能性动脉粥样硬化显著正相关；早期牙周炎的调整OR值为1.76(1.04~3.01)，晚期牙周炎的调整OR值为1.95(1.05~3.63)。结论老年功能性动脉粥样硬化患者牙周炎与慢性肾脏病显著正相关。对于那些没有功能性动脉粥样硬化的患者，没有观察到显著的相关性。这些结果有助于阐明牙周炎对体循环的影响。
AimThis study aimed to clarify the influence of functional atherosclerosis on the association between periodontitis and chronic kidney disease (CKD).Materials and MethodsA cross‐sectional study of 998 older Japanese individuals aged 60–99 years who participated in an oral health check‐up was conducted. Early and advanced periodontitis were defined as periodontal pocket depth of 4.0–5.9 mm and ≥6.0 mm, respectively. Functional atherosclerosis was defined as cardio‐ankle vascular index ≥9.0.ResultsOf the 998 study participants, 238 (23.8%) had CKD. No significant associations between periodontitis and CKD were observed in participants without functional atherosclerosis. After adjusting for known cardiovascular risk factors, the odds ratio (OR) (95% confidence interval [CI]) was 1.31 (0.81–2.11) for early periodontitis and 0.74 (0.41–1.34) for advanced periodontitis. Significant positive associations were observed for participants with functional atherosclerosis; the adjusted ORs (95% CIs) were 1.76 (1.04–3.01) for early periodontitis and 1.95 (1.05–3.63) for advanced periodontitis.ConclusionsA significant positive association between periodontitis and CKD was established for older participants with functional atherosclerosis. No significant associations were observed for those without functional atherosclerosis. These results can help clarify the influence of periodontitis on systemic circulation.