Multiple intracranial lesions with lung adenocarcinoma: A rare case of MOG- IgG-associated encephalomyelitis
Multiple intracranial lesions with lung adenocarcinoma: A rare case of MOG- IgG-associated encephalomyelitis
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颅内多发病变伴肺腺癌：一例 MOG-IgG 相关脑脊髓炎罕见病例
DOI：
10.1016/j.msard.2020.102064
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发表时间：
2020-07-01
影响因子：
4
通讯作者：
Shen, Xiangmin
中科院分区：
文献类型：
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作者：
Li, Ke;Zhan, Yajing;Shen, Xiangmin
背景：髓鞘少突胶质细胞糖蛋白是少突胶质细胞表面的重要标志，与多种脱髓鞘疾病有关。近年来，免疫球蛋白相关脑脊髓炎(MOG-EM)被认为是一种具有初步诊断标准的疾病实体。据报道，一些肺癌患者的肿瘤神经抗体呈阳性；然而，患有MOG-EM的肺癌病例以前没有报道过。方法：我们报告一例在分子靶向治疗中发现的肺腺癌合并多发性颅内病变的病例。结果：患者脑脊液MOG抗体检测阳性，激素治疗效果良好。结论：这是报道的首例颅内多发病变合并肺癌的MOG-EM病例。当患者有恶性肿瘤病史或疑似副肿瘤神经综合征时，临床医生也应警惕其他自身免疫抗体的存在，如MOG-Ig G，以避免延误治疗。
Background: Myelin oligodendrocyte glycoprotein (MOG) is an important marker on the surface of oligoden- drocytes and is associated with many demyelinating diseases. Recently, MOG-IgG-associated encephalomyelitis (MOG-EM) has been proposed as a disease entity with a preliminary diagnosis standard. Some patients with lung cancer have been reported to be seropositive for onconeural antibodies; however, lung cancer cases with MOG- EM have not been previously reported. Methods: We report the case of a patient with lung adenocarcinoma with multiple intracranial lesions found during molecular targeted therapy. Results: The patient tested positive for MOG antibody in her cerebrospinal fluid, and the therapeutic effect of steroids was excellent. Conclusion: This is the first reported case of MOG-EM coincident with lung cancer in a patient with multiple intracranial lesions. When patients present with a history of malignant tumors or suspected paraneoplastic neurological syndrome, clinicians should also be alert to the presence of other autoimmune antibodies such as MOG-IgG to avoid treatment delay.