Understanding layer 4 of the cortical circuit: A model based on cat V1
Understanding layer 4 of the cortical circuit: A model based on cat V1
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DOI：
10.1093/cercor/13.1.73
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发表时间：
2003-01-01
期刊：
影响因子：
3.7
通讯作者：
Miller, KD
中科院分区：
文献类型：
--
作者：
Miller, KD
本文综述了猫初级视皮层(V1)第四层(输入接受层)加工的理论和实验结果。可以从一个模型中理解广泛的实验数据，在该模型中，第四层细胞的反应调节在很大程度上取决于前馈兴奋(来自丘脑)和前馈抑制(来自丘脑驱动的第四层抑制中间神经元)的局部相互作用。前馈抑制支配兴奋，继承丘脑输入的调谐，使兴奋性细胞的调谐更敏锐。细胞接收到的前馈抑制中至少有一个强成分在空间上与它所接收的兴奋相反，这意味着在由光驱动兴奋的视野区域中，抑制是由黑暗驱动的，反之亦然。相反抑制的概念可以概括为由输入模式驱动的抑制，这些输入模式与刺激细胞的模式强烈反相关。本文认为，优势前馈抑制可能是大脑皮层第四层的一般原理。这导致了柱状组织的特性--在皮质垂直深度上的不变性--可能是相反的(反相关的)刺激对所共有的特性。这与一种更常见的观点形成了鲜明对比，即一列代表了一组拥有相似刺激偏好的细胞。
This paper reviews theoretical and experimental results on the processing of layer 4, the input-recipient layer, of cat primary visual cortex (V1). A wide range of experimental data can be understood from a model in which response tuning of layer 4 cells is largely determined by a local interplay of feedforward excitation (from thalamus) and feedforward inhibition (from layer 4 inhibitory interneurons driven by thalamus). Feedforward inhibition dominates excitation, inherits its tuning from the thalamic input and sharpens the tuning of excitatory cells. At least a strong component of the feedforward inhibition received by a cell is spatially opponent to the excitation it receives, meaning that inhibition is driven by dark in regions of the visual field in which excitation is driven by light, and vice versa. The idea of opponent inhibition can be generalized to mean inhibition driven by input patterns that are strongly anti-correlated with the patterns that excite a cell. This paper argues that dominant feedforward opponent inhibition may be a general principle of cortical layer 4. This leads to the suggestion that the properties that show columnar organization - invariance across the vertical depth of cortex - may be properties that are shared by 'opposite' (anticorrelated) stimulus pairs. This contrasts with the more common idea that a column represents a set of cells that all share similar stimulus preferences.