Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells
Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells
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DOI：
10.1158/0008-5472.can-05-0924
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发表时间：
2005-08-01
期刊：
影响因子：
11.2
通讯作者：
Cochran, BH
中科院分区：
文献类型：
--
作者：
Konnikova, L;Simeone, MC;Cochran, BH
信号转导子和转录激活子3（STAT 3）是在细胞因子和生长因子信号传导中起关键作用的转录因子，并且在人类肿瘤中频繁被激活。人端粒酶逆转录酶（hTERT）也经常在肿瘤细胞中过表达并介导细胞永生化。在这里，我们报告说，STAT3直接调节多种人类癌细胞中hTERT的表达。此外，STAT3活性是许多人类肿瘤存活所必需的，并且hTERT表达有助于STAT3依赖性肿瘤细胞的存活。此外，我们发现生长因子和细胞因子以STAT3依赖的方式刺激人原代细胞中hTERT的表达。因此，STAT3是正常细胞和肿瘤细胞中hTERT表达的关键调节因子。
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that plays a critical role in cytokine and growth factor signaling and is frequently activated in human tumors. Human telomerase reverse transcriptase (hTERT) is also often overexpressed in tumor cells and mediates cellular immortalization. Here we report that STAT3 directly regulates the expression of hTERT in a variety of human cancer cells. Moreover, STAT3 activity is required for the survival of many human tumors, and hTERT expression contributes to the survival of STAT3-dependent tumor cells. In addition, we find that growth factors and cytokines stimulate hTERT expression in primary human cells in a STAT3-dependent manner. Thus, STAT3 is a key regulator of hTERT expression in both normal and tumor cells.