Prevalence and predictors of spontaneous preterm births in Nepal: findings from a prospective, population-based pregnancy cohort in rural Nepal-a secondary data analysis.
Prevalence and predictors of spontaneous preterm births in Nepal: findings from a prospective, population-based pregnancy cohort in rural Nepal-a secondary data analysis.
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DOI：
10.1136/bmjopen-2022-066934
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发表时间：
2022-12-01
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
早产可能会给孩子带来短期和长期的并发症。社会经济因素和妊娠相关的发病率可能对预测和预防低资源环境中的早产很重要。本研究的目的是寻找尼泊尔农村自发性早产的患病率和预测因素。这是对试验数据的二次观察性分析（注册号NCT 01177111）。尼泊尔Sarlahi县农村。从2010年9月9日至2017年1月16日入组了40 119例妊娠女性。结局变量为自发性早产。广义估计方程泊松回归稳健方差拟合目前的影响估计的风险比。自发性早产的患病率为14.5%（0.5%非自发性）。与早产风险增加相关的妊娠期无变化的特征是母亲年龄小于18岁（调整后的风险比=1.13，95% CI：1.02至1.26）;穆斯林（1.53，1.16至2.01）;首次怀孕（1.15，1.04至1.28）;多胞胎（4.91，4.20至5.75）和男孩（1.10，1.02至1.17）。与风险降低相关的是母亲教育>5年（0.81，0.73至0.90）;母亲身高≥150 cm（0.89，0.81至0.98）和来自富裕家庭（0.83，0.74至0.93）。与早产风险增加相关的妊娠相关疾病为阴道出血（1.53，1.08至2.18）;肿胀（1.37，1.17至1.60）;妊娠晚期收缩压（BP）高（1.47，1.08至2.01）和舒张压高（1.41，1.17至1.70）。与风险降低相关的是妊娠晚期的呼吸问题（0.86，0.79 ~ 0.94）;妊娠中期食欲不振、恶心、呕吐（0.86，0.80至0.92）和晚期妊娠（0.86，0.79至0.94）;以及从中期到晚期妊娠（0.89，0.87至0.90）的体重增加更高。尼泊尔农村地区的早产率很高。增加产妇教育的干预措施可能会发挥作用。在产前保健期间监测发病率，通过有效的卫生系统进行干预，减少发病率，可能有助于减少早产。
Preterm birth can have short-term and long-term complications for a child. Socioeconomic factors and pregnancy-related morbidities may be important to predict and prevent preterm births in low-resource settings. The objective of our study was to find prevalence and predictors of spontaneous preterm birth in rural Nepal. This is a secondary observational analysis of trial data (registration number NCT01177111). Rural Sarlahi district, Nepal. 40 119 pregnant women enrolled from 9 September 2010 to 16 January 2017. The outcome variable is spontaneous preterm birth. Generalized Estimating Equations Poisson regression with robust variance was fitted to present effect estimates as risk ratios. The prevalence of spontaneous preterm birth was 14.5% (0.5% non-spontaneous). Characteristics not varying in pregnancy associated with increased risk of preterm birth were maternal age less than 18 years (adjusted risk ratio=1.13, 95% CI: 1.02 to 1.26); being Muslim (1.53, 1.16 to 2.01); first pregnancy (1.15, 1.04 to 1.28); multiple births (4.91, 4.20 to 5.75) and male child (1.10, 1.02 to 1.17). Those associated with decreased risk were maternal education >5 years (0.81, 0.73 to 0.90); maternal height ≥150 cm (0.89, 0.81 to 0.98) and being from wealthier families (0.83, 0.74 to 0.93). Pregnancy-related morbidities associated with increased risk of preterm birth were vaginal bleeding (1.53, 1.08 to 2.18); swelling (1.37, 1.17 to 1.60); high systolic blood pressure (BP) (1.47, 1.08 to 2.01) and high diastolic BP (1.41, 1.17 to 1.70) in the third trimester. Those associated with decreased risk were respiratory problem in the third trimester (0.86, 0.79 to 0.94); having poor appetite, nausea and vomiting in the second trimester (0.86, 0.80 to 0.92) and third trimester (0.86, 0.79 to 0.94); and higher weight gain from second to third trimester (0.89, 0.87 to 0.90). The prevalence of preterm birth is high in rural Nepal. Interventions that increase maternal education may play a role. Monitoring morbidities during antenatal care to intervene to reduce them through an effective health system may help reduce preterm birth.
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影响因子：
3.1
作者：
Alamneh TS;Teshale AB;Worku MG;Tessema ZT;Yeshaw Y;Tesema GA;Liyew AM;Alem AZ
通讯作者：
Alem AZ
影响因子：
3.3
作者：
Gurung, Abhishek;Wrammert, Johan;Ashish, K. C.
通讯作者：
Ashish, K. C.
影响因子：
3.8
作者：
Kildea, Sue V.;Gao, Yu;Barclay, Lesley M.
通讯作者：
Barclay, Lesley M.
DOI：
10.1186/s41043-016-0072-y
发表时间：
2016-10-21
期刊：
Journal of health, population, and nutrition
影响因子：
--
作者：
Gernand AD;Paul RR;Ullah B;Taher MA;Witter FR;Wu L;Labrique AB;West KP Jr;Christian P
通讯作者：
Christian P
影响因子：
1.5
作者：
Choi, Jeung-Im;Cho, Mi-Ock;Choi, Gyu-Yeon
通讯作者：
Choi, Gyu-Yeon