Oral L-Citrulline Supplementation Attenuates Blood Pressure Response to Cold Pressor Test in Young Men
Oral L-Citrulline Supplementation Attenuates Blood Pressure Response to Cold Pressor Test in Young Men
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DOI：
10.1038/ajh.2009.195
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
Vicil, Florence
中科院分区：
文献类型：
--
作者：
Figueroa, Arturo;Trivino, Julian A.;Vicil, Florence
背景口服 L-瓜氨酸可有效转化为 L-精氨酸，已被证明可以降低静息时和冷加压试验 (CPT) 期间的肱动脉血压 (BP)。然而，主动脉血压可能比肱动脉血压更好地反映心血管风险。本研究的目的是检验口服左旋瓜氨酸补充剂可减弱肱动脉血压和主动脉血压对 CPT 的血流动力学反应的假设。方法对 17 名年轻（21.6 +/- 0.9 岁）血压正常男性在静息和 CPT 期间的肱动脉血压、主动脉血压、每搏输出量 (SV) 和波反射进行评估。受试者在交叉设计中被随机分配接受 4 周的口服 L-瓜氨酸（6 克/天）或安慰剂组。每次治疗后重新评估对 CPT 的血流动力学反应。 结果在 CPT 期间，肱动脉和主动脉血压 [收缩压 (SBP)、舒张压 (DBP) 和脉压 (PP)]、增强指数 (Alx)、SV 显着增加 (P < 0.05)，并且反射波传播时间 (Tr) 较基线显着减少。与安慰剂相比，口服 L-瓜氨酸治疗在 CPT 期间降低了 (P < 0.05) 肱动脉 SBP (-6 +/- 11 mm Hg)、主动脉 SBP (-4 +/- 10 mm Hg) 和主动脉 PP (-3 +/- 6 mm Hg)，但在休息时则没有这种情况。补充 L-瓜氨酸后，CPT 期间主动脉 SBP 和 Tr 的变化之间存在负相关（r = -0.40，P < 0.05）。结论我们得出结论，口服 L-瓜氨酸补充剂可减弱年轻血压正常男性的肱动脉 SBP、主动脉 SBP 和主动脉 PP 对 CPT 的反应。波反射时间的增加有助于减少主动脉 SBP 对 CPT 的反应。
BACKGROUNDOral L-Citrulline is efficiently converted to L-arginine, which has been shown to decrease brachial blood pressure (BP) at rest and during the cold pressor test (CPT). However, aortic BP may better reflect cardiovascular risk than brachial BP. The purpose of this study was to test the hypothesis that oral L-Citrulline supplementation attenuates brachial BP and aortic hemodynamic responses to CPT.METHODSBrachial BP, aortic BP, stroke volume (SV), and wave reflection at rest and during CPT were evaluated in 17 young (21.6 +/- 0.9 years) normotensive men. Subjects were randomly assigned to 4 weeks of oral L-citrulline (6g/day) or placebo in a crossover design. Hemodynamic responses to CPT were reevaluated after each treatment.RESULTSDuring CPT, there were significant (P < 0.05) increases in brachial and aortic BP [systolic (SBP), diastolic (DBP), and pulse pressure (PP)], augmentation index (Alx), SV, and a decrease in transit time of the reflected wave (Tr) from baseline. Compared to placebo, oral L-citrulline treatment decreased (P < 0.05) brachial SBP (-6 +/- 11 mm Hg), aortic SBP (-4 +/- 10 mm Hg), and aortic PP (-3 +/- 6 mm Hg) during CPT but not at rest. There was an inverse correlation (r = -0.40, P < 0.05) between changes in aortic SBP and Tr during CPT after L-citrulline supplementation.CONCLUSIONSWe conclude that oral L-Citrulline supplementation attenuates the brachial SBP, aortic SBP, and aortic PP responses to CPT in young normotensive men. Increased wave reflection time contributes to the reduction in aortic SBP response to CPT.