Effects of nimodipine and/or haloperidol on the expression of conditioned locomotion and sensitization to cocaine in rats
Effects of nimodipine and/or haloperidol on the expression of conditioned locomotion and sensitization to cocaine in rats
复制标题
尼莫地平和/或氟哌啶醇对大鼠条件运动表达和可卡因敏化的影响
作者：
M. Martin;A. R. Reimer
可卡因的运动效应的经典条件反射的发展可以与通过共同施用氟哌啶醇（多巴胺D2样受体拮抗剂）和尼莫地平（L型钙通道拮抗剂）对可卡因的致敏性的发展分离。本报告描述了这些药物对条件反射和敏化表达的影响。大鼠注射溶剂或可卡因（10 mg/kg，IP）10天，然后放置在记录自发活动的特定环境中。无论是氟哌啶醇（0.05毫克/公斤，IP），也不尼莫地平（10毫克/公斤，SC）影响可卡因的运动效应的经典条件反射的表达，在随后的无可卡因测试的情景背景。两种药物联合治疗大鼠确实阻断了可卡因的经典条件反射。尼莫地平，而不是氟哌啶醇，阻断可卡因的行为敏感化的表达后，可卡因的挑战。可卡因诱导的经典条件反射的表达可以与可卡因行为敏化的表达相分离。此外，尼莫地平和氟哌啶醇对条件反射和敏化的表达的影响不同于它们对这些现象的发展的影响。
The development of classical conditioning of cocaine's locomotor effects can be dissociated from the development of sensitization to cocaine by co-administration of haloperidol, a dopamine D2-like receptor antagonist, and nimodipine, an L-type calcium channel antagonist. The effects of these agents on theexpression of conditioning and sensitization are described in the present report. Rats were given injections of vehicle or cocaine (10 mg/kg, IP) for 10 days before placement in a specific context in which locomotor activity was recorded. Neither haloperidol (0.05 mg/kg, IP) nor nimodipine (10 mg/kg, SC) influenced the expression of classical conditioning of cocaine's locomotor effects to the situational context on a subsequent cocaine-free test. Combined treatment of rats with both drugs did block classical conditioning with cocaine. Nimodipine, but not haloperidol, blocked the expression of behavioural sensitization to cocaine after a cocaine challenge. It is concluded that the expression of cocaine-induced classical conditioning can be pharmacologically dissociated from the expression of behavioural sensitization to cocaine. Furthermore, the effects of nimodipine and haloperidol on the expression of conditioning and sensitization are different from their effects on the development of these phenomena.
条件性多巴胺能活动。
影响因子：
10.6
作者：
Schiff,SR
通讯作者：
Schiff,SR
影响因子：
1.9
作者：
L. Gold;N. Swerdlow;G. Koob
通讯作者：
L. Gold;N. Swerdlow;G. Koob
DOI：
--
发表时间：
1988-02
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Charles P. O'Brien;Childress Ar;I. Arndt;Mclellan At;G. Woody;I. Maany
通讯作者：
Charles P. O'Brien;Childress Ar;I. Arndt;Mclellan At;G. Woody;I. Maany