REGIONAL VARIATIONS IN PROLIFERATION RATE AND DEGREE OF DIFFERENTIATION IN B-16 MELANOMAS
REGIONAL VARIATIONS IN PROLIFERATION RATE AND DEGREE OF DIFFERENTIATION IN B-16 MELANOMAS
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DOI：
10.1007/bf02890294
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
BUYSSENS, N
中科院分区：
文献类型：
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作者：
PAULUS, G;LI, XH;BUYSSENS, N
在可移植的B16黑色素瘤[小鼠]的不同区域中研究了增殖率和分化程度之间的关系。研究的区域是肿瘤的外周部分和所谓的索状结构的内部（血管周围）和外部（外部）区域。最高的增殖率和最差的细胞分化（估计的前黑素体和黑素体的体积密度）发生在血管周围区的索状结构。细胞增殖率最低，细胞分化最好的是在索状结构的外部区域。肿瘤周边部分的增殖率和细胞分化介于索状结构的血管周围或外部区域中获得的值之间。索状结构的结果表明，增殖率和分化程度之间的负相关关系，和增殖能力和血管接近度之间的正相关关系。肿瘤外周部分的中间值可能反映了存在混合细胞群，这些细胞群在最近的血管附近变化。
The relationship between proliferation rate and degree of differentiation was studied in different regions of transplantable B16 melanomas [mouse]. The regions studied were peripheral parts of the tumors and the inner (perivascular) and outer (external) zones of so-called corded structures. The highest proliferation rates and the poorest cellular differentiation (estimated by volume densities of premelanosomes and melanosomes) occurred in the perivascular zones of corded structures. The lowest proliferation rates and the best cellular differentiation was encountered in the external zones of corded structures. Proliferation rates and cellular differentiation in the peripheral parts of the tumors were intermediate between the values obtained in the perivascular or external regions of corded structures. The results in corded structures indicate an inverse relationship between proliferation rate and degree of differentiation, and a positive correlation between proliferative capacity and blood vessel proximity. The intermediate values in the peripheral parts of tumors may reflect the presence of a mixed population of cells which vary in their proximity to the nearest blood vessel.