Pupillary responses to a cognitive effort task in schizophrenia
Pupillary responses to a cognitive effort task in schizophrenia
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DOI：
10.1016/j.schres.2018.03.005
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发表时间：
2018-09-01
影响因子：
4.5
通讯作者：
Green, Michael F.
中科院分区：
文献类型：
--
作者：
Reddy, L. Felice;Reavis, Eric A.;Green, Michael F.
基于努力的决策范式越来越多地被用来深入了解动机缺陷的本质。虽然这些任务被用来评估精神分裂症的努力和动机，很少有工作已经做了确认，努力为基础的决策任务有效地操纵努力。在目前的研究中，我们适应了努力的组成部分，认知努力为基础的决策任务（甲板选择努力任务）与瞳孔评估。我们试图用心理生理学来证实认知努力是被操纵的。我们还研究了努力消耗和认知和阴性症状的生理指标之间的相关性。结果证实了操纵的认知努力：有一个显着的差异，瞳孔反应之间的简单和困难的任务条件。瞳孔反应也与认知能力相关，当控制认知时与阴性症状相关。因此，我们的研究结果提供了生理验证的努力操纵包括在认知努力为基础的决策任务精神分裂症。由爱思唯尔公司出版
Effort-based decision making paradigms are increasingly utilized to gain insight into the nature of motivation deficits. Although these tasks are being used to assess effort and motivation in schizophrenia, little work has been done to confirm that effort-based decision making tasks validly manipulate effort. In the current study, we adapted the effort component a cognitive effort-based decision making task (the Deck Choice Effort Task) for use with pupillometric assessment. We sought to confirm with psychophysiology that cognitive effort is manipulated. We also examined correlations between physiological indicators of effort exertion and cognition and negative symptoms. The results confirmed manipulation of cognitive effort: there was a significant difference in pupillary responses between easy and difficult task conditions. Pupillary responses were also correlated with cognitive ability, and with negative symptoms when controlling for cognition. Thus, our findings offer physiological validation of an effort manipulation included in a cognitive effort-based decision making task for schizophrenia. Published by Elsevier B.V.