ACUTE HEMORRHAGIC, HEPATIC, AND NEUROLOGIC MANIFESTATIONS IN JUVENILE RHEUMATOID-ARTHRITIS - POSSIBLE RELATIONSHIP TO DRUGS OR INFECTION
ACUTE HEMORRHAGIC, HEPATIC, AND NEUROLOGIC MANIFESTATIONS IN JUVENILE RHEUMATOID-ARTHRITIS - POSSIBLE RELATIONSHIP TO DRUGS OR INFECTION
复制标题
DOI：
10.1016/s0022-3476(85)80072-x
复制
发表时间：
1985-01-01
影响因子：
5.1
通讯作者：
GRISCELLI, C
中科院分区：
文献类型：
--
作者：
HADCHOUEL, M;PRIEUR, AM;GRISCELLI, C
7例幼年型类风湿性关节炎患儿出现以出血和神经、肝脏、血液和代谢表现为特征的综合征。这种疾病似乎不符合Reye综合征或任何其他已知实体的特征。这种严重的并发症可能是由药物或并发感染引起的巨噬细胞激活引起的。数据表明，红细胞沉降率或血小板和纤维蛋白原水平的突然下降可能标志着这种并发症的开始，并可能是快速类固醇治疗的指征。
Seven children with juvenile rheumatoid arthritis had a syndrome characterized by hemorrhage and neurologic, hepatic, hematologic and metabolic manifestations. The disease did not seem to conform clearly to the characteristics of Reye syndrome or any other well-known entity. This severe complication may be induced by macrophage activation secondary to a drug or intercurrent infection. Data suggest that a sudden fall in erythrocyte sedimentation rate or in platelet and fibrinogen levels may mark the start of this complication and may be an indication for rapid steroid therapy.