Symptoms and duration of the prodromal phase in Parkinson's disease
Symptoms and duration of the prodromal phase in Parkinson's disease
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DOI：
10.1002/mds.870120607
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发表时间：
1997-11-01
影响因子：
8.6
通讯作者：
Horstink, WIM
中科院分区：
文献类型：
--
作者：
Gonera, EG;vantHof, M;Horstink, WIM
为了研究特发性帕金森病的典型症状发作前的前驱症状持续时间，作者对60名帕金森病患者和58名年龄和性别匹配的对照受试者进行了一项回溯性病例对照研究，涵盖了典型帕金森病发病前十年的时间。这些症状来自患者的全科医生档案。与对照组相比，帕金森病前期患者有更多的中枢神经系统、心理、肌肉骨骼和心血管(即自主神经)症状。帕金森氏症前期患者也更多地去看全科医生和内科专家。结果表明，典型帕金森综合征的发病前通常有一个持续4-6年的前驱期。
To investigate the duration of a prodromal phase before the onset of the classic symptoms of idiopathic Parkinson's disease, the authors conducted a retrospective case-control study of 60 patients with Parkinson's disease and 58 age-and sex-matched control subjects, covering the decade preceding the onset of classic Parkinson's disease. The symptoms were derived from files of the patients' general practitioners. Compared with control subjects, patients pre-Parkinson's disease had more central nervous system, psychologic, musculoskeletal, and cardiovascular (i.e., autonomic) symptoms. Patients pre-Parkinson's disease also made more visits to general practitioners and medical specialists. The results indicate that the onset of classic parkinsonism is frequently preceded by a prodromal phase lasting from 4-6 years.