Effect of Bone Morphogenetic Protein 6 on Immunomodulatory Functions of Salivary Gland-Derived Mesenchymal Stem Cells in Sjogren's Syndrome
Effect of Bone Morphogenetic Protein 6 on Immunomodulatory Functions of Salivary Gland-Derived Mesenchymal Stem Cells in Sjogren's Syndrome
复制标题
骨形态发生蛋白6对干燥综合征唾液腺间充质干细胞免疫调节功能的影响
DOI：
10.1089/scd.2017.0161
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发表时间：
2018
影响因子：
4
通讯作者：
Wang Hao
中科院分区：
文献类型：
--
作者：
Xu Junji;Su Yingying;Hu Lei;Cain Alex;er;Gu Yi;Liu Bowen;Wu Ruiqing;Wang Songlin;Wang Hao
干燥综合征 (SS) 的特点是自身免疫激活和唾液腺功能丧失。最近的研究报道，骨形态发生蛋白6（BMP6）是转化生长因子β（TGF-β）超家族的成员，在SS患者中高表达。为了研究 BMP6 在 SS 中的作用，我们用 BMP6 处理唾液腺源性间充质干细胞 (SGMSC)，发现 BMP6 可以通过 DNA 结合蛋白抑制剂-1 下调前列腺素 E2 合酶，从而损害正常 SGMSC 的免疫调节特性。中和BMP6可以在体外显着恢复SGMSC的免疫调节功能，并在体内延缓SS疾病活动。总之，BMP6不仅可以影响唾液腺上皮细胞的分泌功能，还可以影响SGMSC的免疫调节特性，从而可能触发或增强SS的自身免疫反射。
Sjögren's syndrome (SS) is characterized by autoimmune activation and loss of function in the salivary glands. Recent studies reported that bone morphogenetic protein 6 (BMP6), which is a member of transforming growth factor beta (TGF-β) superfamily, was highly expressed in SS patients. To investigate the role of BMP6 in SS, we treated the salivary gland-derived mesenchymal stem cells (SGMSCs) with BMP6 and found that BMP6 could impair immunomodulatory properties of normal SGMSCs by downregulating the Prostaglandin E2 synthase through DNA-binding protein inhibitor-1. Neutralizing the BMP6 could significantly restore the SGMSC's immunoregulatory function in vitro and delay the SS disease activity in vivo. In conclusion, BMP6 could not only affect the secreting function of epithelial cells in the salivary gland but also influence the immunomodulatory properties of SGMSCs, which may trigger or enhance the autoimmune reflection in SS.