THE SEMAPHORIN GENES ENCODE A FAMILY OF TRANSMEMBRANE AND SECRETED GROWTH CONE GUIDANCE MOLECULES
THE SEMAPHORIN GENES ENCODE A FAMILY OF TRANSMEMBRANE AND SECRETED GROWTH CONE GUIDANCE MOLECULES
复制标题
DOI：
10.1016/0092-8674(93)90625-z
复制
发表时间：
1993-12-31
期刊：
影响因子：
64.5
通讯作者：
GOODMAN, CS
中科院分区：
文献类型：
--
作者：
KOLODKIN, AL;MATTHES, DJ;GOODMAN, CS
除了在轴突亚群上表达外，蝗虫Semaphorin I(SEMA I，以前称为Fasciclin[Fas]IV)表达在肢芽的一条上皮条上，在两个感觉生长锥体遇到SEMA I边界时突然转向时，它起着指导作用。我们在这里报道了果蝇中两个SEMA基因的克隆和特性，以及两个相关的病毒序列的鉴定，它们都编码具有保守的Semaphorin结构域的蛋白质。果蝇SEMA(D-Sema)I是一种跨膜蛋白，而D-Sema II和人类Sema III是可能的分泌型蛋白，与最近报道的鸡崩溃蛋白相似。D-Sema I和D-Sema II由神经元和肌肉亚群表达。对果蝇的遗传分析表明，SemaII是一种对于正常的成年行为和生存都是必需的基因。
In addition to its expression on subsets of axons, grasshopper Semaphorin I (Sema I, previously called Fasciclin [Fas] IV) is expressed on an epithelial stripe in the limb bud, where it functions in the guidance of two sensory growth cones as they abruptly turn upon encountering this sema I boundary. We report here on the cloning and characterization of two sema genes in Drosophila, one in human, and the identification of two related viral sequences, all of which encode proteins with conserved Semaphorin domains. Drosophila, sema (D-Sema) I is a transmembrane protein, while D-Sema II and human Sema III are putative secreted proteins that are similar to the recently reported chick collapsin. D-Sema I and D-Sema II are expressed by subsets of neurons and muscles. Genetic analysis in Drosophila reveals that semaII is an essential gene that is required for both proper adult behavior and survival.