CYTOSKELETAL ALTERATIONS MIGHT ACCOUNT FOR THE PHYLOGENETIC VULNERABILITY OF THE HUMAN BRAIN TO ALZHEIMERS-DISEASE
CYTOSKELETAL ALTERATIONS MIGHT ACCOUNT FOR THE PHYLOGENETIC VULNERABILITY OF THE HUMAN BRAIN TO ALZHEIMERS-DISEASE
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DOI：
10.1016/0306-9877(91)90187-4
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发表时间：
1991-02-01
影响因子：
4.7
通讯作者：
DIPATRE, PL
中科院分区：
文献类型：
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作者：
DIPATRE, PL
这里提出一个理论，试图解释为什么阿尔茨海默病（AD）主要影响最近在发育过程中获得的人脑区域。 细胞骨架功能的紊乱在触发一系列病理事件中发挥着重要作用，导致AD相关组织病理学标记物的出现以及神经元的变性和死亡。 这些缺陷被认为更可能发生在具有高度可塑性的神经元群体中，这些神经元群体是记忆功能的基质，事实上，它们构成了人类大脑中遗传学上新的端脑区域。
A theory is presented here in the attempt to explain why Alzheimer's disease (AD) primarily affects areas of the human brain that have been acquired recently in phylogenesis. Disturbances in cytoskeletal function are proposed to play a fundamental role in triggering the sequence of pathologic events leading to the occurrence of AD-related histopathological markers and to the degeneration and death of neurons. These deficits are supposed to occur more likely in neuronal populations that possess a high degree of plasticity, the substrate of memory functions, and that constitute, in fact, the phylogenetically new telencephalic regions of the human brain.