Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters
Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters
复制标题
小鼠对旋毛虫原发性和攻击性感染的免疫：常规参数的重新检查
作者：
D. Wakelin;M. Lloyd
在幼龄(6-8周龄)近交系小鼠中，原发感染旋毛虫的第n株近交系小鼠在第8天开始排出旋毛虫，到第11·5天基本排出完毕。在老年小鼠中，排出早1~2天。初次感染的经历激发了对挑战的强烈免疫力，无论挑战是在驱虫后立即给予(第14天)还是延迟给予(第42天)。挑战感染被迅速驱除，大多数蠕虫在第一天就消失了。对挑战的免疫是由低水平的原发感染引起的，对大型挑战感染有效。这些结果与传统上接受的小鼠对旋毛虫的免疫参数有关，这些参数被认为只适用于对这种寄生虫的遗传决定的低水平反应的小鼠。
In young (6- to 8-week-old) NTH strain inbred mice expulsion of a primary infection of Trichinella spiralis began on day 8 and was virtually complete by day 11·5. In older mice expulsion occurred 1 or 2 days earlier. Experience of a primary infection elicited strong immunity to challenge, whether the challenge was given immediately after worm expulsion (day 14) or delayed (day 42). Challenge infections were expelled rapidly, the majority of worms being lost during the first day. Immunity to challenge was elicited by low-level primary infections and was effective against large challenge infections. These results are discussed in relation to conventionally accepted parameters of immunity to T. spiralis in mice which, it is considered, are applicable only to mice with a genetically-determined low-level of responsiveness to the parasite.