Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans.
Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans.
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DOI：
10.1016/0024-3205(96)00396-7
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发表时间：
1996-01-01
期刊：
影响因子：
6.1
通讯作者：
Watson, R R
中科院分区：
文献类型：
--
作者：
Araghiniknam, M;Chung, S;Watson, R R
山药是一种山药类固醇提取物，用于商业合成类固醇，供人们食用。脱氢表雄酮是一种类固醇，随着年龄的增长而下降，但没有已知的活性。这项研究旨在确定补充山药是否可以增加人类血清中的脱氢表雄酮硫酸酯(DHEAS)，并调节老年人的血脂水平。受试者为年龄65-82岁的志愿者。测定血清DHEAS水平、脂质过氧化反应和血脂谱。补充山药3周对血清DHEAS水平无影响。然而，每天摄入85 mg脱氢表雄酮可使血清脱氢表雄酮水平增加100.3%。DHEA和山药能显著降低血清脂质过氧化，降低血清甘油三酯、磷脂，升高高密度脂蛋白水平。脱氢表雄酮和类固醇山药提取物，山药，具有显著的抗氧化剂活性，以改善血脂水平。
Dioscorea is a yam steroid extract used in commercial steroid synthesis and consumed by people. DHEA is a steroid which declines with age, but without known activity. This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people. The subjects were selected volunteers aged 65-82 years. The serum DHEAS level, lipid peroxidation and lipid profile were assessed. Three weeks of dioscorea supplementation had no affect on serum DHEAS level. However DHEA intake of 85 mg/day increased serum DHEA levels 100.3%. DHEA and dioscorea significantly reduced serum lipid peroxidation, lowered serum triglycerides, phospholipid and increased HDL levels. Both DHEA and the steroid yam extract, dioscorea, have significant activities as antioxidant to modify serum lipid levels.