EFFECT OF THE 5-HT1A RECEPTOR AGONIST 8-OH-DPAT ON THE RELEASE OF 5-HT IN DORSAL AND MEDIAN RAPHE-INNERVATED RAT-BRAIN REGIONS AS MEASURED BY INVIVO MICRODIALYSIS
EFFECT OF THE 5-HT1A RECEPTOR AGONIST 8-OH-DPAT ON THE RELEASE OF 5-HT IN DORSAL AND MEDIAN RAPHE-INNERVATED RAT-BRAIN REGIONS AS MEASURED BY INVIVO MICRODIALYSIS
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DOI：
10.1016/0024-3205(91)90216-x
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发表时间：
1991-01-01
期刊：
影响因子：
6.1
通讯作者：
SHARP, T
中科院分区：
文献类型：
--
作者：
HJORTH, S;SHARP, T
最近的电生理学研究，5-HT合成的测量和5-HT代谢的在体伏安法记录表明，中缝正中核（MR）的胆碱能神经元对5-HT 1A自身受体刺激的敏感性低于中缝背核（DR）。 为了进一步研究从中缝核上行5-HT投射之间的调节的假定差异，我们使用微透析来测量腹侧海马、苍白球、背侧海马、额叶皮质、丘脑核和内侧隔中5-HT的释放，在全身施用特异性5-HT 1A激动剂8-OH-DPAT之后。 结果表明，5-羟色胺的基线输出是相似的，在每个研究领域。 虽然8-OH-DPAT降低了所有区域的透析液5-HT水平，但与其他五个区域相比，苍白球中观察到的5-HT释放抑制作用显著降低。 结果表明，5-HT 1A自身受体介导的5-HT释放的控制在所研究的所有脑区都是有功能的，包括那些接受来自DR和MR的优先5-HT神经支配的脑区。苍白球，然而代表了一个可能的例外。
Recent electrophysiological studies, measurements of 5-HT synthesis and in vivo voltammetry recordings of 5-HT metabolism have suggested that serotoninergic neurones in the median raphe (MR) are less sensitive to 5-HT1A autoreceptor stimulation relative to those in the dorsal raphe (DR). To further study the putative differences in regulation between ascending 5-HT projections from the raphe nuclei we have used microdialysis to measure the release of 5-HT in ventral hippocampus, globus pallidus, dorsal hippocampus, frontal cortex, nucleus accumbens and medial septum, following systemic administration of the specific 5-HT1A agonist 8-OH-DPAT. The results show that the baseline output of 5-HT was similar in each of the areas studied. While 8-OH-DPAT decreased dialysate levels of 5-HT in all areas, the inhibition of 5-HT release seen in globus pallidus was significantly less marked compared to that observed in the other five regions. The results indicate that 5-HT1A autoreceptor-mediated control of 5-HT release is functional in all of the brain areas studied, including those receiving a preferential 5-HT innervation from the DR and MR. We find little evidence in support of the idea that brain 5-HT neuronal projections are heterogenous with respect to 5-HT1A autoreceptor regulation of 5-HT release; the globus pallidus, however representing a possible exception to this.