Melodinines M-U, Cytotoxic Alkaloids from Melodinus suaveolens
Melodinines M-U, Cytotoxic Alkaloids from Melodinus suaveolens
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DOI：
10.1021/np2009169
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发表时间：
2012-02-01
影响因子：
5.1
通讯作者：
Luo, Xiao-Dong
中科院分区：
文献类型：
--
作者：
Liu, Ya-Ping;Li, Yan;Luo, Xiao-Dong
从甜黑瓜中分离得到9个新生物碱，命名为Melodinines M-U（1-9）和11个已知生物碱。通过广泛的NMR和质谱分析以及与已知化合物的比较来阐明新结构。评价所有化合物对五种人癌细胞系的细胞毒性。化合物6、11和16显示出显著的细胞毒性。
Nine new alkaloids, melodinines M-U (1-9), and 11 known alkaloids were isolated from Melodinus suaveolens. The new structures were elucidated by extensive NMR and mass spectroscopic analyses and comparison to known compounds. All compounds were evaluated for their cytotoxicity against five human cancer cell lines. Compounds 6, 11, and 16 showed significant cytotoxicity.