Limited susceptibility of mice to Usutu virus (USUV) infection and induction of flavivirus cross-protective immunity
Limited susceptibility of mice to Usutu virus (USUV) infection and induction of flavivirus cross-protective immunity
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DOI：
10.1016/j.virol.2015.03.020
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发表时间：
2015-08-01
期刊：
影响因子：
3.7
通讯作者：
Saiz, Juan-Carlos
中科院分区：
文献类型：
--
作者：
Blazquez, Ana-Belen;Escribano-Romero, Estela;Saiz, Juan-Carlos
黄病毒是一种核糖核酸病毒，对全球人类和动物健康构成令人担忧的威胁。在欧洲，西尼罗河病毒(WNV)暴发的数量和严重程度近年来急剧增加，整个大陆已有数十人和马死亡，禽类死亡率居高不下。除西尼罗河病毒外，到目前为止在欧洲发现的唯一具有临床相关性的蚊媒黄病毒是Usutu病毒(USUV)，自2001年在奥地利首次报告后，该病毒迅速传播到欧洲各地，导致相当多的禽类死亡和少数免疫功能受损的患者出现神经疾病。尽管USUV感染了多种产生抗体的禽类，但关于USUV的易感性、致病性和交叉反应免疫的信息很少。在这里，乳鼠和成年小鼠对USUV感染的易感性以及对WNV攻击的交叉保护性免疫的诱导进行了讨论。(C)2015 Elsevier Inc.保留所有权利。
Flaviviruses are RNA viruses that constitute a worrisome threat to global human and animal health. In Europe, West Nile virus (WNV) outbreaks have dramatically increased in number and severity in recent years, with dozens of human and horse deaths and a high avian mortality across the continent. Besides WNV, the only clinically relevant mosquito-borne flavivirus detected so far in Europe has been the Usutu virus (USUV), which after being reported for the first time in Austria in 2001, quickly spread across Europe, causing a considerable number of bird deaths and neurological disorders in a few immuno-compromised patients. Even though USUV infects multiple avian species that develop antibodies, there is little information about USUV susceptibility, pathogenicity and cross-reactive immunity. Here, the susceptibility of suckling and adult mice to USUV infection and the induction of cross-protective immunity against WNV challenge have been addressed. (C) 2015 Elsevier Inc. All rights reserved.