Protective effects of astaxanthin on a combination of D-galactose and jet lag-induced aging model in mice
Protective effects of astaxanthin on a combination of D-galactose and jet lag-induced aging model in mice
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DOI：
10.1507/endocrj.ej17-0500
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发表时间：
2018-01-01
影响因子：
2
通讯作者：
Fu, Zhengwei
中科院分区：
文献类型：
--
作者：
Ni, Yinhua;Wu, Tao;Fu, Zhengwei
氧化应激引起的自由基和线粒体损伤在细胞和组织水平的衰老和年龄相关损伤的进展中起着关键作用。抗氧化剂的补充越来越受到关注，抗氧化剂对衰老的影响越来越多地在动物和人体研究中进行评估。然而，需要有助于扩展抗衰老疗法的其他和更有前途的治疗方法。虾青素是一种超级抗氧化剂类胡萝卜素和自由基清除剂，比维生素E更有效地抑制脂质过氧化。在本研究中，我们使用加速衰老模型研究了虾青素对衰老的预防作用：小鼠长期接受D-半乳糖和时差的组合治疗。治疗6周后，虾青素给药倾向于保护老年小鼠的肝脏重量减轻。这可能是通过上调半乳糖-1-磷酸尿苷转移酶的mRNA表达，从而促进D-半乳糖代谢。在游泳试验中，补充虾青素还提高了老年小鼠的肌肉耐力。这些结果与血清中氧化应激降低和体内抗氧化酶活性和mRNA表达增加有关。此外，虾青素逆转了小鼠肝脏和肾脏中由D-半乳糖和时差综合作用引起的衰老相关基因表达失调。结论：在D-半乳糖和喷气延迟诱导的衰老模型中，虾青素通过降低氧化应激和提高衰老相关基因的表达，防止肝脏重量减轻，改善运动肌肉功能，发挥显著的抗衰老作用。
Oxidative stress caused free radical and mitochondrial damage plays a critical role in the progression of aging and age-related damage at the cellular and tissue levels. Antioxidant supplementation has received growing attention and the effects of antioxidant on aging are increasingly assessed in both animal and human studies. However, additional and more promising treatments that contribute to the expansion of anti-aging therapies are needed. Astaxanthin, a super antioxidant carotenoid and free radical scavenger, inhibits lipid peroxidation more potently than vitamin E. In the present study, we investigated the preventative effects of astaxanthin on aging using an accelerated aging model: mice chronically treated with a combination of D-galactose and jet lag. After 6 weeks of treatment; astaxanthin administration tended to protect the liver weight loss in aged mice. It is probably by upregulating the mRNA expression of galactose-1-phosphate uridyltransferase, which contribute to the enhancement of D-galactose metabolism. Astaxanthin supplementation also improved muscle endurance of aged mice in a swimming test. These results were associated with reduced oxidative stress in serum and increased anti-oxidative enzymes activities and mRNA expression in vivo. Moreover, astaxanthin reversed the dysregulation of aging-related gene expression caused by the combination of D-galactose and jet lag in the liver and kidney of mice. In conclusion, astaxanthin prevents liver weight loss, ameliorates locomotive muscular function, exerts significant anti-aging effects by reducing oxidative stress and improving the expression of age-related genes in D-galactose and jet lag-induced aging model.