Thymidylate synthase and dihydropyrimidine dehydrogenase expression in oral squamous cell carcinoma: an immunohistochemical and clinicopathologic study.
Thymidylate synthase and dihydropyrimidine dehydrogenase expression in oral squamous cell carcinoma: an immunohistochemical and clinicopathologic study.
复制标题
胸苷酸合成酶和二氢嘧啶脱氢酶在口腔鳞状细胞癌中的表达：免疫组织化学和临床病理学研究。
DOI：
--
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
A. Mizuno
中科院分区：
文献类型：
--
作者：
G. Kawasaki;I. Yoshitomi;S. Yanamoto;A. Mizuno
OBJECTIVE
Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU), and dihydropyrimidine dehydrogenase (DPD) is the first enzyme that metabolizes 5-fluorouracil. Until now, only the enzyme activities of TS and DPD have been investigated; however, there are few reports about the immunohistochemistry of TS and DPD and none regarding oral carcinoma. The purpose of this article was to investigate the expression of TS and DPD in oral squamous cell carcinoma.
STUDY DESIGN
In this study, 109 oral squamous cell carcinomas were investigated for the immunohistochemical expression of TS and DPD proteins.
RESULTS
The expressions of TS in carcinoma cases was significantly higher than in controls (P <.05, t test). DPD was expressed both in carcinomas and in areas adjacent to the carcinomas. There was no correlation between the clinical factors and the TS labeling index or between the clinical factors and the DPD labeling index (DPD-LI). Pathologically, DPD-LI was significantly different in both the World Health Organization classification and Anneroth's classification. The TS labeling index was significantly correlated with the Ki-67 LI (P <.05, Pearson's correlation coefficient). Although TS showed no correlation between tegafur-uracil response and TS labeling index, there was a significant correlation between the tegafur-uracil response and DPD-LI.
CONCLUSIONS
TS may reveal tumor cell proliferation, but DPD-LI may correlate with a response to anticancer drug treatment.
影响因子：
11.2
作者：
P. Johnston;H. Lenz;C. Leichman;K. Danenberg;C. Allegra;P. Danenberg;L. Leichman
通讯作者：
P. Johnston;H. Lenz;C. Leichman;K. Danenberg;C. Allegra;P. Danenberg;L. Leichman
胸苷酸合酶蛋白水平的增加主要与异步人类癌细胞的增殖有关，但与细胞周期阶段无关。
影响因子：
8.8
作者：
Pestalozzi,BC;McGinn,CJ;Kinsella,TJ;Drake,JC;Glennon,MC;Allegra,CJ;Johnston,PG
通讯作者：
Johnston,PG
影响因子：
45.3
作者：
Leichman, CG;Lenz, HJ;Danenberg, PV
通讯作者：
Danenberg, PV