Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells.
Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells.
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家族性肾细胞癌，3;11 染色体易位仅限于肿瘤细胞。
DOI：
10.1126/science.7112106
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Trindade,A
中科院分区：
文献类型：
--
作者：
Pathak,S;Strong,LC;Ferrell,RE;Trindade,A
本文对一例家族性肾细胞癌患者的肾细胞癌细胞和培养的外周血淋巴细胞进行了直接染色体制片和细胞遗传学研究。结果显示，一个特定的，获得性易位（3 p; 11 p）存在于大多数中期的肿瘤，表明肾细胞癌的发展与3 p近端的缺失。因此，肾细胞癌是第三个例子-前两个是视网膜母细胞瘤和肾母细胞瘤-染色体缺失发生生殖或体细胞与特定的肿瘤。这一发现进一步支持了特定人类癌症基因的存在。
Cytogenetic studies were performed on the direct chromosome preparations of the renal cell carcinoma cells and the cultured peripheral blood lymphocytes of a patient with familial renal cell carcinoma. The results revealed a specific, acquired translocation (3p;11p) present in the majority of metaphases of the tumor, indicating that the development of renal cell carcinoma is associated with a deletion in the proximal end of 3p. Renal cell carcinoma is thus the third example—the first two being retinoblastoma and Wilms' tumor—of a chromosomal deletion occurring germinally or somatically in association with a specific tumor. This finding adds further support to the existence of specific human cancer genes.