Standard and modified statistical MUNE evaluations in spinal-bulbar muscular atrophy.
Standard and modified statistical MUNE evaluations in spinal-bulbar muscular atrophy.
复制标题
DOI：
10.1002/mus.21399
复制
发表时间：
2009-11
期刊：
影响因子：
3.4
通讯作者：
Floeter, Mary Kay
中科院分区：
文献类型：
--
作者：
Lehky, Tanya J.;Chen, Cheun Ju;Di Prospero, Nicholas A.;Rhodes, Lindsay E.;Fischbeck, Kenneth;Floeter, Mary Kay
MUNE, a technique used in ALS clinical trials to quantitatively assess motor neuron loss, should also be valuable in assessing progression in spinal bulbar muscular atrophy (SBMA), an x-linked neuronopathy. In ALS, instability of single motor units (SMUP) prompted Shefner to modify the statistical MUNE method to exclude SMUPs ≤ 40μV. It is unknown if there is a similar SMUP instability in the more chronic degenerative disease of SBMA. In this study, the standard parameter of excluding SMUP < 10 μV was compared with the exclusion of SMUP < 40 μV in the calculation of the statistical MUNE. The mean statistical MUNE, using the standard method and the Shefner method, was 60±21 to 47±23, respectively. Similar to ALS, SBMA showed an increased proportion (17%) of individual SMUPs ≤ 40 μV compared to normal controls. In conclusion, excluding SMUPs ≤ 40 μV from the statistical MUNE calculations is appropriate for SBMA subjects because their SMUPs characteristics are similar to ALS. Exclusion of the low amplitude SMUPs reduces the calculated MUNE.
登录
查看更多内容
影响因子：
9.9
作者：
Chahin, Nizar;Klein, Christopher;Sorenson, Eric
通讯作者：
Sorenson, Eric
影响因子：
3.4
作者：
Kwon, O;Lee, KW
通讯作者：
Lee, KW
影响因子：
3.4
作者：
Henderson, RD;McClelland, R;Daube, JR
通讯作者：
Daube, JR
影响因子：
--
作者：
Gooch, CL;Shefner, JM
通讯作者：
Shefner, JM
影响因子：
3.4
作者：
Shefner, JM;Cudkowicz, ME;Jillapalli, D
通讯作者：
Jillapalli, D