Brain perfusion SPECT with an automated quantitative tool can identify prodromal Alzheimer's disease among patients with mild cognitive impairment
Brain perfusion SPECT with an automated quantitative tool can identify prodromal Alzheimer's disease among patients with mild cognitive impairment
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DOI：
10.1016/j.neurobiolaging.2009.01.013
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发表时间：
2011-01-01
影响因子：
4.2
通讯作者：
Dubois, Bruno
中科院分区：
文献类型：
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作者：
Habert, Marie-Odile;Horn, Jean-Francois;Dubois, Bruno
目的：通过结合脑灌注单光子发射计算机断层扫描 (SPECT) 图像和记忆测试评分的自动化定量工具，提高早期阿尔茨海默病 (AD)（即前驱 AD）的诊断，以便应用于临床实践。 患者和方法：在这项前瞻性、纵向、多中心研究中，对 83 名有记忆障碍和轻度认知障碍 (MCI) 的患者进行了基线 Tc-99m-ECD 灌注 SPECT。经过3年的随访，11名患者进展为阿尔茨海默病（MCI-AD组），72名患者保持稳定（MCI-S组），其中1名患者出现轻度血管性认知障碍。使用基于体素的方法对 MCI-S 和 MCI-AD 组进行比较后，从统计上显着的聚类中提取区域掩模，并单独使用或与自由和提示选择性提醒测试 (FCSRT) 分数结合使用，使用线性判别分析对受试者进行分类。使用留一交叉验证方法对结果进行验证。结果：右侧顶叶和海马灌注显着（p
Objective: To improve diagnosis of early Alzheimer's disease (AD), i.e., prodromal AD, by an automated quantitative tool combining brain perfusion single-photon emission computed tomography (SPECT) images and memory tests scores in order to be applied in clinical practice.Patients and methods: In this prospective, longitudinal, multi-centric study, a baseline Tc-99m-ECD perfusion SPECT was performed in 83 patients with memory complaint and mild cognitive impairment (MCI). After a 3-year follow-up, 11 patients progressed to Alzheimer's disease (MCI-AD group), and 72 patients remained stable (MCI-S group), including 1 patient who developed mild vascular cognitive impairment. After comparison between the MCI-S and MCI-AD groups with a voxel-based approach, region masks were extracted from the statistically significant clusters and used alone or in combination with Free and Cued Selective Reminding Test (FCSRT) scores for the subject's categorization using linear discriminant analysis.Results were validated using the leave-one-out cross-validation method. Results: Right parietal and hippocampal perfusion was significantly (p