The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study
The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study
复制标题
DOI：
10.1016/j.jad.2017.10.028
复制
发表时间：
2018-02-01
影响因子：
6.6
通讯作者：
Kennedy, Sidney H.
中科院分区：
文献类型：
--
作者：
Baskaran, Anusha;Farzan, Faranak;Kennedy, Sidney H.
背景：本研究旨在多部位比较脑电频段活动，包括大脑半球间不对称性和前额叶西他普兰在治疗后8周预测疗效的有效性。方法：由加拿大抑郁症生物标记物整合网络(CAN-BIND)进行的一项更大规模、多部位发现抗抑郁药物治疗反应的生物标志物研究中，记录了44名确诊为重度抑郁障碍患者的静息状态通道脑电数据。在治疗后8周测量临床反应，作为基线Montgomery-Asberg抑郁评定量表(MADRS)评分50%或以上的变化。在(1)治疗前基线(2)治疗后2周和(3)作为“早期改变”变量(定义为从治疗前到治疗后2周的脑电改变)进行脑电测量分析。结果：在基线时，治疗应答者左侧大脑半球的绝对阿尔法功率升高，而无应答者则相反。应答者进一步表现出顶叶区域的皮质不对称。两组在治疗前的相对增量功率上也存在差异，应答者在右半球表现出比左半球更大的能量，而非应答者则表现出相反的情况。在治疗后2周，应答者左半球的绝对β功率比右半球更大，而无应答者则相反。在治疗后2周，绝对和相对增量功率呈现相反的模式。应答者表现出相对α功率的早期减少和相对θ功率的早期增加。无反应者的前额叶theta波早期显著增加。结论：在治疗前和治疗后2周，阿尔法和德尔塔频段的半球不对称对预测抗抑郁药物治疗的反应有较强的预测作用。
Background: This study aims to compare the effectiveness of EEG frequency band activity including interhemispheric asymmetry and prefrontal theta cordance in predicting response to escitalopram therapy at 8-weeks post-treatment, in a multi-site initiative.Methods: Resting state 64-channel EEG data were recorded from 44 patients with a diagnosis of major depressive disorder (MDD) as part of a larger, multisite discovery study of biomarkers in antidepressant treatment response, conducted by the Canadian Biomarker Integration Network in Depression (CAN-BIND). Clinical response was measured at 8-weeks post-treatment as change from baseline Montgomery-Asberg Depression Rating Scale (MADRS) score of 50% or more. EEG measures were analyzed at (1) pre-treatment baseline (2) 2 weeks post-treatment and (3) as an "early change" variable defined as change in EEG from baseline to 2 weeks posttreatment.Results: At baseline, treatment responders showed elevated absolute alpha power in the left hemisphere while non-responders showed the opposite. Responders further exhibited a cortical asymmetry in the parietal region. Groups also differed in pre-treatment relative delta power with responders showing greater power in the right hemisphere over the left while non-responders showed the opposite. At 2 weeks post-treatment, responders exhibited greater absolute beta power in the left hemisphere relative to the right and the opposite was noted for non-responders. A reverse pattern was noted for absolute and relative delta power at 2 weeks post-treatment.Responders exhibited early reductions in relative alpha power and early increments in relative theta power. Non-responders showed a significant early increase in prefrontal theta cordance.Conclusions: Hemispheric asymmetries in the alpha and delta bands at baseline and at 2 weeks post-treatment have moderately strong predictive utility in predicting response to antidepressant treatment.