OVARIAN SURFACE EPITHELIUM, OVULATION AND CARCINOGENESIS
OVARIAN SURFACE EPITHELIUM, OVULATION AND CARCINOGENESIS
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DOI：
10.1111/j.1469-185x.1996.tb01283.x
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发表时间：
1996-11
影响因子：
10
通讯作者：
W. Murdoch
中科院分区：
文献类型：
--
作者：
W. Murdoch
卵巢表面上皮细胞与促性腺激素刺激的排卵前卵泡接触后，似乎可以释放生物活性物质，削弱白膜和卵泡顶壁（如胶原溶解酶）并诱导细胞死亡（如凋亡剂）。然而，卵巢表面上皮在排卵中的决定性强制性作用仍不明确。从卵泡圆顶脱落的上皮细胞通过生殖干细胞复制和从伤口边缘迁移而得到补充。诱变与连续的排卵和有丝分裂有关。普通上皮性卵巢癌是一种致命的潜伏性疾病，主要是因为直到恶性肿瘤到达卵巢以外时才无症状。最重要的易感因素是未生育和与患病一级亲属的关联。这将是至关重要的，以确定是否胎次和口服避孕药的使用赋予显著保护妇女卵巢癌家族史。显然，需要创新的非侵入性筛查和治疗方法。早期发现是挽救生命的关键（如果诊断在第一阶段，90%的治愈率仅靠输卵管卵巢切除术）。确定肿瘤表位的主动免疫或（被动）腹腔内给药效应功能人源化抗体可能在普通上皮性卵巢癌的区域管理中具有特殊价值。
It appears that ovarian surface epithelial cells activated by contact with gonadotropin-stimulated preovulatory follicles can release bioactive substances that weaken the tunica albuginea and apical follicular wall (e.g. collagenolytic enzymes) and induce cell death (e.g. apoptotic agents). However, a definitive obligatory role of the ovarian surface epithelium in ovulation remains equivocal. Epithelium exfoliated from the dome of ovulatory follicles is replenished by generative stem cell replication and migration from the wound edges. Mutagenesis has been related to successive bouts of ovulation and mitosis. Common epithelial ovarian cancer is a deadly insidious disease, mainly because it is asymptomatic until the malignancy has reached beyond the ovaries. The most important susceptibility factors are nulliparity and association to an affected first-degree relative. It will be critical to resolve whether parity and oral contraceptive use confer significant protection to women with a family history of ovarian carcinoma. Clearly, innovative approaches to non-invasive screening and treatment are needed. Early detection is the key to saving lives (90% cure by salpingo-ovariectomy alone if diagnosis is at Stage I). Active immunization with defined tumor epitopes or (passive) intraperitoneal administration of effector-functional humanized antibodies may be of special value in the regional management of common epithelial ovarian cancer.