Initial experience with the development and numerical and in vitro studies of a novel low-pressure artificial right ventricle for pediatric Fontan patients
Initial experience with the development and numerical and in vitro studies of a novel low-pressure artificial right ventricle for pediatric Fontan patients
复制标题
DOI：
10.1097/01.mat.0000249038.69048.3c
复制
发表时间：
2006-11-01
期刊：
影响因子：
4.2
通讯作者：
Shandas, Robin
中科院分区：
文献类型：
--
作者：
Wang, Rui;Lacour-Gayet, Francois G.;Shandas, Robin
Fontan手术是一种有效的姑息性手术，适用于单心室病变患者。全腔静脉连接术是首选Fontan手术，其中将上级和下腔静脉连接到左肺动脉和右肺动脉。本工作的总体目标是开发一种可引入下腔静脉的人工右心室，这将有助于逆转Fontan术后患者的有害血流动力学。我们提出了一个微型轴流泵的初步设计和计算分析，设计与特定的血液动力学的Fontan生理铭记。还介绍了原型泵的初步体外数据。计算研究表明，新设计可以提供各种有利的操作条件，包括通过近端抽吸降低静脉压、增加泵内压力升高、增加肺流量以及最小化上级腔静脉压变化。在体外研究的规模原型显示出类似的趋势，所看到的计算。我们的结论是，微型轴流泵可以设计成有效地运行在低压，低流量的环境中的空腔流。这些结果鼓励了将这种设计用于体外研究和动物研究。
The Fontan operation, an efficient palliative surgery, is performed for patients with single-ventricle pathologies. The total cavopulmonary connection is a preferred Fontan procedure in which the superior and inferior vena cava are connected to the left and right pulmonary artery.The overall goal of this work is to develop an artificial right ventricle that can be introduced into the inferior vena cava, which would act to reverse the deleterious hemodynamics in post-Fontan patients. We present the initial design and computational analysis of a micro-axial pump, designed with the particular hemodynamics of Fontan physiology in mind. Preliminary in vitro data on a prototype pump are also presented. Computational studies showed that the new design can deliver a variety of advantageous operating conditions, including decreased venous pressure through proximal suction, increased pressure rise across the pump, increased pulmonary flows, and minimal changes in superior vena cava pressures. In vitro studies on a scaled prototype showed trends similar to those seen computationally. We conclude that a micro-axial flow pump can be designed to operate efficiently within the low-pressure, low-flow environment of cavopulmonary flows. The results provide encouragement to pursue this design to for in vitro studies and animal studies.