Lack of association between augmentation mammoplasty and systemic sclerosis (scleroderma).
Lack of association between augmentation mammoplasty and systemic sclerosis (scleroderma).
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隆乳术和系统性硬化症（硬皮病）之间缺乏关联。
DOI：
10.1002/art.1780390708
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发表时间：
1996
影响因子：
--
通讯作者：
Wigley,FM
中科院分区：
文献类型：
--
作者：
Hochberg,MC;Perlmutter,DL;MedsgerJr,TA;Nguyen,K;Steen,V;Weisman,MH;White,B;Wigley,FM
Objective.研究隆乳术与系统性硬化症（SSc;硬皮病）之间的可能联系。837名临床诊断为SSc的女性，作为志愿者样本从3个大学三级硬皮病临床研究中心招募，2,507名种族匹配的当地对照女性，通过随机数字拨号和年龄频率匹配的技术招募，完成了一份问卷，提供了隆乳术史的数据，包括手术可能的并发症。通过调整年龄、种族和研究中心的多变量Logistic回归分析和调整年龄的条件Logistic回归分析，估计隆乳术与SSc相关性的比值比（OR）和95%置信区间（95%CI）。837例患者中有11例（1.31%）在诊断SSc之前报告了隆乳术史，而2,507例对照中有31例（1.24%）。非配对分析的调整OR为1.07（95%CI 0.53-2.13），配对分析的调整OR为1.11（95%CI 0.55-2.24）。这些结果未能证明隆乳术和SSc之间存在显著相关性，并且与其他流行病学研究报告的结果一致。
Objective. To examine the possible association between augmentation mammoplasty and systemic sclerosis (SSc; scleroderma).Methods. Eight hundred thirty‐seven women with a clinical diagnosis of SSc, recruited as a volunteer sample from 3 university‐based, tertiary care scleroderma clinical research centers, and 2,507 race‐matched local control women, recruited by the technique of random‐digit‐dialing and frequency‐matched on age, completed a questionnaire providing data on history of augmentation mammoplasty, including possible complications of the procedure. The odds ratio (OR) and 95 percent confidence interval (95% CI) for the association of augmentation mammoplasty with SSc were estimated by multivariate logistic regression analysis with adjustment for age, race and center, and by conditional logistic regression analysis with adjustment for age.Results. Eleven (1.31%) of the 837 cases reported a history of augmentation mammoplasty prior to diagnosis of SSc, compared with 31 (1.24%) of the 2,507 controls. The adjusted OR from the unmatched analysis was 1.07 (95% CI 0.53–2.13), while that from the matched analysis was 1.11 (95% CI 0.55–2.24).Conclusion. These results fail to demonstrate a significant association between augmentation mammoplasty and SSc, and are consistent with those reported from other epidemiologic studies.