Lung cancer incidence in never smokers
Lung cancer incidence in never smokers
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DOI：
10.1200/jco.2006.07.2983
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发表时间：
2007-02-10
影响因子：
45.3
通讯作者：
West, Dee W.
中科院分区：
文献类型：
--
作者：
Wakelee, Heather A.;Chang, Ellen T.;West, Dee W.
目的肺癌是世界范围内癌症死亡的主要原因。虽然吸烟仍然是肺癌的主要原因，但从不吸烟者患肺癌是一个日益突出的公共卫生问题。然而，关于这一主题的数据，特别是肺癌发病率在从不吸烟者，是limited.MethodsWe审查了现有的文献肺癌发病率和死亡率之间从不吸烟者和目前的新数据率从不吸烟者从以下大型前瞻性队列：护士健康研究;卫生专业人员随访研究;加州教师研究;多种族队列研究;瑞典乌普萨拉/厄勒布鲁地区肺癌登记处;和第一次全国健康和营养检查调查流行病学随访研究。结果在这六个队列中，年龄40至79岁的从不吸烟者中肺癌的截短年龄调整发病率为14.4至20.8/100，女性为4.8 - 13.7/100，000人-年，男性为4.8 - 13.7/100，000人-年，支持早期观察结果，即女性比男性更容易患非吸烟相关肺癌。不同的生物学肺癌在从不吸烟者是显而易见的差异反应表皮生长因子受体抑制剂和腺癌组织学在never smokers.ConclusionLung cancer in never smokers is a important public health issue，and further exploration of its incidence patterns，病因学和生物学是必要的。
PurposeLung cancer is a leading cause of cancer death worldwide. Although smoking remains the predominant cause of lung cancer, lung cancer in never smokers is an increasingly prominent public health issue. However, data on this topic, particularly lung cancer incidence rates in never smokers, are limited.MethodsWe reviewed the existing literature on lung cancer incidence and mortality rates among never smokers and present new data regarding rates in never smokers from the following large, prospective cohorts: Nurses' Health Study; Health Professionals Follow-Up Study; California Teachers Study; Multiethnic Cohort Study; Swedish Lung Cancer Register in the Uppsala/Orebro region; and First National Health and Nutrition Examination Survey Epidemiologic Follow-Up Study.ResultsTruncated age-adjusted incidence rates of lung cancer among never smokers age 40 to 79 years in these six cohorts ranged from 14.4 to 20.8 per 100,000 person-years in women and 4.8 to 13.7 per 100,000 person-years in men, supporting earlier observations that women are more likely than men to have non-smoking-associated lung cancer. The distinct biology of lung cancer in never smokers is apparent in differential responses to epidermal growth factor receptor inhibitors and an increased prevalence of adenocarcinoma histology in never smokers.ConclusionLung cancer in never smokers is an important public health issue, and further exploration of its incidence patterns, etiology, and biology is needed.