Local brain functional activity following early deprivation:: A study of postinstitutionalized Romanian orphans
Local brain functional activity following early deprivation:: A study of postinstitutionalized Romanian orphans
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DOI：
10.1006/nimg.2001.0917
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发表时间：
2001-12-01
期刊：
影响因子：
5.7
通讯作者：
Chugani, DC
中科院分区：
文献类型：
--
作者：
Chugani, HT;Behen, ME;Chugani, DC
早期对机构儿童的全面剥夺可能导致持续的特定认知和行为缺陷。为了检查这些缺陷背后的脑功能障碍，我们对罗马尼亚孤儿院收养的10名儿童（6男4女，平均年龄8.8岁）进行了2-脱氧-2-[F-18]氟-d -葡萄糖正电子发射断层扫描。采用统计参数映射（SPM），将孤儿的脑糖代谢模式与两个对照组的模式进行比较：(i)一组17名正常成年人（9名男性，8名女性，平均年龄27.6岁）和（ii）一组7名患有难治性局灶性癫痫，但对侧半球糖代谢模式正常的儿童（5名男性和2名女性，平均年龄10.7岁）。与之前对罗马尼亚孤儿院收养儿童的研究一致，本研究中对罗马尼亚孤儿的神经心理学评估显示出轻度神经认知障碍、冲动、注意力和社交缺陷。与正常成年人相比，罗马尼亚孤儿在眶额回、边缘下前额叶皮层、内侧颞叶结构（杏仁核和海马体头）、外侧颞叶皮层和脑干的代谢显著降低。使用区域利益方法证实了这些发现。SPM分析显示，与儿童癫痫对照组的非癫痫半球相比，孤儿大脑同一区域的葡萄糖代谢显著降低。这些大脑区域的功能障碍可能是由于早期全球剥夺的压力造成的，可能与一些罗马尼亚孤儿表现出的长期认知和行为缺陷有关。(C) 2001学术出版社。
Early global deprivation of institutionalized children may result in persistent specific cognitive and behavioral deficits. In order to examine brain dysfunction underlying these deficits, we have applied positron emission tomography using 2-deoxy-2-[F-18]fluoro-D-glucose in 10 children (6 males, 4 females, mean age 8.8 years) adopted from Romanian orphanages. Using statistical parametric mapping (SPM), the pattern of brain glucose metabolism in the orphans was compared to the patterns obtained from two control groups: (i) a group of 17 normal adults (9 males, 8 females, mean age 27.6 years) and (ii) a group of 7 children (5 males and 2 females, mean age 10.7 years) with medically refractory focal epilepsy, but normal glucose metabolism pattern in the contralateral hemisphere. Consistent with previous studies of children adopted from Romanian orphanages, neuropsychological assessment of Romanian orphans in the present study showed mild neurocognitive impairment, impulsivity, and attention and social deficits. Comparing the normalized glucose metabolic rates to those of normal adults, the Romanian orphans showed significantly decreased metabolism bilaterally in the orbital frontal gyrus, the infralimbic prefrontal cortex, the medial temporal structures (amygdala and head of hippocampus), the lateral temporal cortex, and the brain stem. These findings were confirmed using a region-of-interest approach. SPM analysis showed significantly decreased glucose metabolism in the same brain regions comparing the orphans to the nonepileptic hemisphere of the childhood epilepsy controls. Dysfunction of these brain regions may result from the stress of early global deprivation and may be involved in the long-term cognitive and behavioral deficits displayed by some Romanian orphans. (C) 2001 Academic Press.