Fewer fractions of adjuvant external beam radiotherapy for early breast cancer are safe and effective and can now be the standard of care
Fewer fractions of adjuvant external beam radiotherapy for early breast cancer are safe and effective and can now be the standard of care
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DOI：
10.1016/j.breast.2010.03.029
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发表时间：
2010-06-01
期刊：
影响因子：
3.9
通讯作者：
Harnett, Adrian
中科院分区：
文献类型：
--
作者：
Harnett, Adrian
多年来，英国各地对单个肿瘤部位的分级治疗方案差异很大。乳腺癌尤其如此，占放射治疗部门工作量的40%。在过去的30年里，许多英国肿瘤中心通过减少分割和常规使用国际非标准方案来应对这种大的病例负荷和缺乏兆伏机器，使得这些方案本身成为标准治疗的选择之一。如今，医学在很大程度上是以证据为基础的，而不是历史上更多地依赖于临床经验或直觉。特别是在英国和加拿大的大型研究开始解决这个问题，并表明在局部复发，晚期组织效应和美观方面，较少的分数是等同的。目前的研究集中在进一步的低分割和部分乳腺放疗（见论文Yarnold（2010）进一步推进“低分割”是否安全？乳房（这个问题）。Lehman（2010）：小于全乳放疗方法。乳房（这个问题））。(C)2010爱思唯尔有限公司版权所有。
Fractionation regimes for individual tumour sites have varied greatly across the UK for many years. This has been particularly true for breast cancer which accounts for up to 40% of a radiotherapy department's work load. Over the last 30 years or so many UK oncology centres have coped with this large case load and a lack of megavoltage machines by reducing fractionation and routinely using internationally non standard regimes so that these regimes have themselves become one of the options for standard treatment. Nowadays, medicine is largely evidence based rather than historically relying more on clinical experience or intuition. Large studies particularly in the UK and Canada set out to address this question and have shown that fewer fractions are equivalent in terms of local recurrence, late tissue effects and cosmesis. Current studies are focusing on further hypofractionation and partial breast radiotherapy (see papers Yarnold (2010) Is it safe to push "hypofractionation" further?. The Breast (this issue). Lehman (2010) The less than whole breast radiotherapy approach. The Breast (this issue)). (C) 2010 Elsevier Ltd. All rights reserved.