Granulocyte-colony stimulating factor promotes invasion by human lung cancer cell lines in vitro
Granulocyte-colony stimulating factor promotes invasion by human lung cancer cell lines in vitro
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DOI：
10.1007/bf00123394
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发表时间：
1996-09-01
影响因子：
4
通讯作者：
Hara, N
中科院分区：
文献类型：
--
作者：
Pei, XH;Nakanishi, Y;Hara, N
使用产生G-CSF的肺癌细胞系（NCI-H157）和不产生G-CSF的细胞系（PC-9和NCI-H23）研究外源性和内源性粒细胞集落刺激因子（G-CSF）对癌细胞侵袭的影响，NCI-H157细胞的侵袭能力比PC-9和NCI-H23细胞高26至27倍。 PC-9细胞受到外源G-CSF的刺激，而NCI-H157则没有，抗G-CSF抗体阻断了外源G-CSF对PC-9细胞侵袭的刺激，抗G-CSF抗体在外源G-CSF不存在的情况下也抑制NCI-H157细胞的侵袭，这些结果表明内源和外源G-CSF均刺激肺癌细胞的侵袭。
The effects of exogenous and endogenous granulocyte colony-stimulating factor (G-CSF) on invasion by cancer cells were studied, using lung cancer cell lines that produce G-CSF (NCI-H157) and lines that do not (PC-9 and NCI-H23), The invasive capacity of NCI-H157 cells was 26- to 27-fold higher than that of PC-9 and NCI-H23 cells, The invasiveness of PC-9 cells was stimulated by exogenous G-CSF, while that of NCI-H157 tells was not, Antibodies against G-CSF blocked the stimulation of PC-9 cell invasiveness by exogenous G-CSF, Anti G-CSF antibodies also inhibited invasion by NCI-H157 cells in the absence of exogenous G-CSF, These results suggest that endogenous and exogenous G-CSF both stimulate invasion by lung cancer cells.