The hnRNP family: insights into their role in health and disease.
The hnRNP family: insights into their role in health and disease.
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DOI：
10.1007/s00439-016-1683-5
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发表时间：
2016-08
期刊：
影响因子：
5.3
通讯作者：
Timmerman V
中科院分区：
文献类型：
--
作者：
Geuens T;Bouhy D;Timmerman V
异质核核糖核蛋白（hnRNPs）代表了一个rna结合蛋白（rbp）大家族，它们参与了核酸代谢的多个方面，包括选择性剪接、mRNA稳定以及转录和翻译调节。许多hnRNPs具有一般特征，但在结构域组成和功能特性上有所不同。本文将讨论目前关于不同hnRNP家族成员的知识，重点讨论它们的结构和功能差异。此外，我们将强调它们在神经退行性疾病和癌症中的作用，以及开发基于rna的疗法的潜力。
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.