PTBP1 promotes the growth of breast cancer cells through the PTEN/Akt pathway and autophagy.
PTBP1 promotes the growth of breast cancer cells through the PTEN/Akt pathway and autophagy.
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PTBP1通过PTEN/Akt通路和自噬促进乳腺癌细胞生长
DOI：
10.1002/jcp.26823
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发表时间：
2018-11
影响因子：
5.6
通讯作者：
Jin F
中科院分区：
文献类型：
--
作者：
Wang X;Li Y;Fan Y;Yu X;Mao X;Jin F
侵袭和转移是恶性肿瘤的标志，也是乳腺癌死亡的主要原因。多聚嘧啶束结合蛋白（PTB）是了解RNA结合蛋白如何影响增殖和侵袭以及这些蛋白表达的变化如何控制肿瘤发生的复杂程序的重要模型。我们研究了多聚嘧啶束结合蛋白1（PTBP 1）在人乳腺癌中的作用。我们发现PTBP 1在乳腺癌组织中的表达高于正常组织，并且在乳腺癌细胞系中也证实了同样的结果。PTBP 1的敲低基本上抑制肿瘤细胞的生长、迁移和侵袭。这些结果表明PTBP 1与乳腺肿瘤发生相关，并且似乎是肿瘤细胞生长和转移维持所需的。我们进一步分析了PTBP 1与临床病理参数的关系，发现PTBP 1与HER-2表达、淋巴结转移和病理分期相关。这将成为HER-2（+）乳腺癌的新靶点。PTBP 1通过调节磷酸酶和张力蛋白同系物-磷脂酰肌醇-4，5-二磷酸3-激酶/蛋白激酶B（PTEN-PI 3 K/Akt）途径和自噬发挥这些作用，从而改变细胞生长并促进侵袭和转移。
Invasion and migration is the hallmark of malignant tumors as well as the major cause for breast cancer death. The polypyrimidine tract binding, PTB, protein serves as an important model for understanding how RNA binding proteins affect proliferation and invasion and how changes in the expression of these proteins can control complex programs of tumorigenesis. We have investigated some roles of polypyrimidine tract binding protein 1 (PTBP1) in human breast cancer. We found that PTBP1 was upregulated in breast cancer tissues compared with normal tissues and the same result was confirmed in breast cancer cell lines. Knockdown of PTBP1 substantially inhibited tumor cell growth, migration, and invasion. These results suggest that PTBP1 is associated with breast tumorigenesis and appears to be required for tumor cell growth and maintenance of metastasis. We further analyzed the relationship between PTBP1 and clinicopathological parameters and found that PTBP1 was correlated with her‐2 expression, lymph node metastasis, and pathological stage. This will be a novel target for her‐2(+) breast cancer. PTBP1 exerts these effects, in part, by regulating the phosphatase and tensin homolog‐phosphatidylinositol‐4,5‐bisphosphate 3‐kinase/protein kinase B (PTEN‐PI3K/Akt) pathway and autophagy, and consequently alters cell growth and contributes to the invasion and metastasis.
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影响因子：
15.9
作者：
McCutcheon, IE;Hentschel, SJ;Cote, GJ
通讯作者：
Cote, GJ
影响因子：
5.6
作者：
Takai T;Yoshikawa Y;Inamoto T;Minami K;Taniguchi K;Sugito N;Kuranaga Y;Shinohara H;Kumazaki M;Tsujino T;Takahara K;Ito Y;Akao Y;Azuma H
通讯作者：
Azuma H
影响因子：
3.7
作者：
Pesson M;Volant A;Uguen A;Trillet K;De La Grange P;Aubry M;Daoulas M;Robaszkiewicz M;Le Gac G;Morel A;Simon B;Corcos L
通讯作者：
Corcos L
影响因子：
5.3
作者：
Sauliere, Jerome;Sureau, Alain;Marie, Joelle
通讯作者：
Marie, Joelle
影响因子：
16
作者：
Xue Y;Zhou Y;Wu T;Zhu T;Ji X;Kwon YS;Zhang C;Yeo G;Black DL;Sun H;Fu XD;Zhang Y
通讯作者：
Zhang Y