Fetal origins of adult disease
Fetal origins of adult disease
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DOI：
10.1016/j.siny.2005.11.001
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发表时间：
2006-04-01
影响因子：
3
通讯作者：
Morley, R
中科院分区：
文献类型：
--
作者：
Morley, R
“胎儿起源的成人疾病”一词是根据大量流行病学研究中发现的两个出生体重与血压、成人发病糖尿病、冠心病和中风之间的负相关性而创造的。然而，出生体重似乎不太可能参与这些观察结果的因果途径，如果是这样，那么这些发现对公共卫生的意义非常有限，因为我们无法在人类中将出生体重修改到相关程度。产妇营养一直是重点。尽管有证据表明，在动物中对母体营养的实验操作会影响后代的出生体重和与心血管疾病相关的计划措施，但人类研究总体上提供的证据有限且不令人信服，表明母体大量营养素摄入的差异很重要。然而，有必要了解潜在的因果途径，并讨论了双胞胎研究的效用和可能的机制。(c)2005爱思唯尔有限公司保留所有权利。
The term 'fetal origins of adult disease' was coined on the basis of the inverse association between tow birth weight and blood pressure, adutt-onset diabetes, coronary heart disease, and stroke seen in numerous epidemiological studies. However, it seems unlikely that birth weight is involved in causal pathways underlying these observations, and if it were then the significance to public health of these findings is very Limited because of our inability to modify birth weight to a relevant extent in humans. There has been a major focus on maternal nutrition. Despite evidence that experimental manipulation of maternal nutrition in animals influences offspring birth weight and programme measures related to cardiovascular disease, human studies in general provide limited and unconvincing evidence that differences in maternal macronutrient intake are important. Nevertheless there is a need to understand the underlying causal pathways, and the utility of studies of twins and possible mechanisms are discussed. (c) 2005 Elsevier Ltd. All rights reserved.