Layer-specific activation in human primary somatosensory cortex during tactile temporal prediction error processing
Layer-specific activation in human primary somatosensory cortex during tactile temporal prediction error processing
复制标题
触觉时间预测误差处理过程中人类初级体感皮层的层特异性激活
DOI：
10.1016/j.neuroimage.2021.118867
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发表时间：
2022
期刊：
影响因子：
5.7
通讯作者：
Bandettini Peter A.
中科院分区：
文献类型：
--
作者：
Yu Yinghua;Huber Laurentius;Yang Jiajia;Fukunaga Masaki;Chai Yuhui;Jangraw David C.;Chen Gang;Handwerker Daniel A.;Molfese Peter J.;Ejima Yoshimichi;Sadato Norihiro;Wu Jinglong;Bandettini Peter A.
人类大脑不断地产生对传入的感觉输入的预测，并根据感知到的输入计算相应的预测误差，以更新内部预测。在人类初级躯体感觉皮层（3b区）中，不同的皮层层参与接收感觉输入和产生错误信号。然而，仍然不知道人类区域3b中的层如何对时间预测误差处理做出贡献。为了研究预测误差表示在区域3b跨层，我们获得层特定的功能磁共振成像（fMRI）数据在7T从人类区域3b在任务的食指戳无延迟，短延迟和长延迟触摸序列。我们证明，所有这三个任务增加了活动在表层和深层的区域3b相比，随机的感觉输入。fMRI信号仅在深层而不是在区域3b的表层被延迟时间差分调制。与无延迟刺激相比，在短延迟刺激时，3b区深层的活动更大，而在长延迟刺激时，活动更小。这种不同的活动特征在表层和深层表明不同的功能贡献的区域3b层触觉时间预测错误处理。区域3b跨层的功能分离可能反映了感觉皮层中的兴奋性和抑制性相互作用对皮层层之间或皮层区域之间的灵活通信的贡献。
The human brain continuously generates predictions of incoming sensory input and calculates corresponding prediction errors from the perceived inputs to update internal predictions. In human primary somatosensory cortex (area 3b), different cortical layers are involved in receiving the sensory input and generation of error signals. It remains unknown, however, how the layers in the human area 3b contribute to the temporal prediction error processing. To investigate prediction error representation in the area 3b across layers, we acquired layer-specific functional magnetic resonance imaging (fMRI) data at 7T from human area 3b during a task of index finger poking with no-delay, short-delay and long-delay touching sequences. We demonstrate that all three tasks increased activity in both superficial and deep layers of area 3b compared to the random sensory input. The fMRI signal was differentially modulated solely in the deep layers rather than the superficial layers of area 3b by the delay time. Compared with the no-delay stimuli, activity was greater in the deep layers of area 3b during the short-delay stimuli but lower during the long-delay stimuli. This difference activity features in the superficial and deep layers suggest distinct functional contributions of area 3b layers to tactile temporal prediction error processing. The functional segregation in area 3b across layers may reflect that the excitatory and inhibitory interplay in the sensory cortex contributions to flexible communication between cortical layers or between cortical areas.
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影响因子：
1.9
作者：
MUMFORD, D
通讯作者：
MUMFORD, D
DOI：
10.1364/josaa.20.001434
发表时间：
2003-07-01
影响因子：
1.9
作者：
Lee, TS;Mumford, D
通讯作者：
Mumford, D
DOI：
10.1073/pnas.1318665111
发表时间：
2014-05-06
影响因子：
11.1
作者：
Mease, Rebecca A.;Krieger, Patrik;Groh, Alexander
通讯作者：
Groh, Alexander
DOI：
10.1006/cbmr.1996.0014
发表时间：
1996-06-01
期刊：
COMPUTERS AND BIOMEDICAL RESEARCH
影响因子：
--
作者：
Cox, RW
通讯作者：
Cox, RW
弥合系统与细胞之间的差距：超高场 MRI 在人类神经科学中的作用。
影响因子：
--
作者：
R. Turner;Daniel D. De Haan
通讯作者：
Daniel D. De Haan