Effects of bone morphogenetic protein‐4 (BMP‐4) on adipocyte differentiation from mouse adipose‐derived stem cells
Effects of bone morphogenetic protein‐4 (BMP‐4) on adipocyte differentiation from mouse adipose‐derived stem cells
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DOI：
10.1111/cpr.12044
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发表时间：
2013-08
影响因子：
8.5
通讯作者：
X. Wei;G. Li;X. Yang;K. Ba;Y. Fu;N. Fu;X. Cai;Q. Chen;M. Wang;Y. Lin
中科院分区：
文献类型：
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作者：
X. Wei;G. Li;X. Yang;K. Ba;Y. Fu;N. Fu;X. Cai;Q. Chen;M. Wang;Y. Lin
由于间充质干细胞（MSC）可以很容易地从脂肪组织中分离出来，同时保留其自我更新和多向分化能力，因此它们在组织工程中具有广泛应用的前景。据报道，骨形态发生蛋白 (BMP) 家族成员可为 MSC 提供指导信号，使其分化为几种不同的细胞谱系。本文描述的研究旨在研究不同浓度下 BMP-4 是否可以促进脂肪源性干细胞 (ASC) 分化为脂肪细胞。
As mesenchymal stem cells (MSCs) can be isolated easily from adipose tissues while retaining their self‐renewal and multi‐potential differentiation capacities, they hold promising possibilities for being applied extensively in tissue engineering. Bone morphogenetic protein (BMP) family members have been reported to provide instructive signals to MSCs for them to differentiate into several different cell lineages. The study described here aims to investigate whether BMP‐4 could promote adipose‐derived stem cell (ASC) differentiation into adipocytes under various concentrations.