Natural history of venous morphologic changes in dialysis access stenosis
Natural history of venous morphologic changes in dialysis access stenosis
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DOI：
10.5301/jva.5000212
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发表时间：
2014-07-01
影响因子：
1.9
通讯作者：
Roy-Chaudhury, Prabir
中科院分区：
文献类型：
--
作者：
Lee, Timmy;Somarathna, Maheshika;Roy-Chaudhury, Prabir
目的：继发于内膜增生的静脉狭窄是早期动静脉内瘘（AVF）失败的主要病因。 AVF 失败的自然史可能受到 AVF 创建之前和之后静脉进行性血管损伤的影响。本研究的主要目的是 (1) 提供非慢性肾脏病 (CKD)、上肢静脉标本的组织学和形态测量描述，以及 (2) 进行形态测量分析以研究非 CKD 上肢静脉、新血管通路手术时收集的静脉以及从失败的狭窄 AVF 收集的静脉的静脉组织学。方法：来自 11 个非 CKD 的静脉样本收集已故供体、29 名接受新血管通路创建的受试者和 20 名狭窄失败 AVF 受试者进行组织学和形态测量分析。结果：从非 CKD 受试者、接受新血管通路受试者和狭窄 AVF 受试者收集的静脉的平均内膜/中层厚度 +/- S.E. 的平均值分别为 0.16 +/- 0.02、0.43 +/- 0.07和 3.84 +/- 0.55（分别为
Purpose: Venous stenosis secondary to neointimal hyperplasia is a major etiology of early arteriovenous fistula (AVF) failure. The natural history of AVF failure is likely influenced by progressive vascular insults to the vein prior to and after AVF creation. The main objectives of this study were to (1) provide a histologic and morphometric description of non-chronic kidney disease (CKD), upper extremity vein specimens and (2) perform a morphometric analysis to study venous histology from non-CKD upper extremity veins, veins collected at the time of new vascular access surgery and veins collected from failed stenotic AVFs.Methods: Vein samples from 11 non-CKD deceased donors, 29 subjects receiving new vascular access creation and 20 subjects with stenotic failed AVFs were collected for histologic and morphometric analysis.Results: The mean values of average intima/media thickness +/- S. E. from veins collected from non-CKD subjects, subjects receiving new vascular access and subjects with stenotic AVFs were 0.16 +/- 0.02, 0.43 +/- 0.07 and 3.84 +/- 0.55, respectively (p