The role of neuroplasticity and cognitive reserve in aging with HIV: recommendations for cognitive protection and rehabilitation.
The role of neuroplasticity and cognitive reserve in aging with HIV: recommendations for cognitive protection and rehabilitation.
复制标题
神经可塑性和认知储备在艾滋病毒衰老中的作用：认知保护和康复建议。
DOI：
10.1097/jnn.0b013e31829d8b29
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Raper,JamesL
中科院分区：
文献类型：
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作者：
Vance,DavidE;Fazeli,PariyaL;Grant,JoanS;Slater,LarryZ;Raper,JamesL
总的来说，艾滋病毒感染者的免疫系统正在受到高效抗逆转录病毒疗法的进步的保护和维持。因此，这正在将人们的寿命延长到老年。不幸的是，对于许多患有这种疾病的人来说，艾滋病毒与神经炎症、并发症和加速衰老有关，这些都会损害大脑功能，导致认知缺陷。本文的目的是强调如何在该临床人群的神经可塑性和认知储备的框架内解释这些缺陷。我们提出了一些认知康复和缓解建议，例如解决生活方式因素、精神兴奋剂、认知矫正疗法以及抑郁和焦虑的治疗。提出了对护理研究和实践的影响。
By and large, the immune systems of people infected with HIV are being protected and maintained by advances in highly active antiretroviral therapy; as such, this is extending the lives of people into old age. Unfortunately, for many living with this disease, HIV is associated with neuroinflammation, co-morbidities, and accelerated aging which can compromise brain function, resulting in cognitive deficits. The purpose of this article is to highlight how to interpret these deficits within the framework of neuroplasticity and cognitive reserve for this clinical population. We suggest several recommendations for cognitive rehabilitation and mitigation such as addressing lifestyle factors, psychostimulants, cognitive remediation therapy, and treatment of depression and anxiety. Implications for nursing research and practice are posited.