Turning blood into brain:: Cells bearing neuronal antigens generated in vivo from bone marrow
Turning blood into brain:: Cells bearing neuronal antigens generated in vivo from bone marrow
复制标题
DOI：
10.1126/science.290.5497.1779
复制
发表时间：
2000-12-01
期刊：
影响因子：
56.9
通讯作者：
McKercher, SR
中科院分区：
文献类型：
--
作者：
Mezey, É;Chandross, KJ;McKercher, SR
骨髓干细胞可产生多种造血系，并在成年后重新补充血液。我们发现，在一组不能发育髓系和淋巴系小鼠的小鼠中，移植的成人骨髓细胞迁移到大脑中，并分化为表达神经元特异性抗原的细胞。这些发现提出了一种可能性，即骨髓来源的细胞可能会为神经退行性疾病或中枢神经系统损伤患者提供另一种神经元来源。
Bone marrow stern cells give rise to a variety of hematopoietic Lineages and repopulate the blood throughout adult Life. We show that, in a strain of mice incapable of developing colts of the myeloid and Lymphoid lineages,transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.