IMMUNOCOMPETENCE AND MALIGNANT-LYMPHOMA - IMMUNOLOGICAL STATUS BEFORE THERAPY
IMMUNOCOMPETENCE AND MALIGNANT-LYMPHOMA - IMMUNOLOGICAL STATUS BEFORE THERAPY
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DOI：
10.1002/1097-0142(19811215)48:12
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发表时间：
1981-01-01
期刊：
影响因子：
6.2
通讯作者：
STANLEY, P
中科院分区：
文献类型：
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作者：
ANDERSON, TC;JONES, SE;STANLEY, P
先前未治疗的恶性淋巴瘤患者（186例）通过免疫功能测试评估免疫能力；总循环淋巴细胞、T细胞（e -莲座）、B细胞（eac -莲座）、对6种召回抗原的延迟性超敏反应、血清Ig、混合淋巴细胞培养和淋巴细胞对植物血凝素和美洲商陆有丝分裂原的有丝分裂反应。结果与组织学、分期及临床特征相关。弥漫性淋巴瘤，尤其是弥漫性组织细胞（大细胞）（DHL），与绝对淋巴细胞和e -花环形成细胞减少有关。皮肤试验反应性随组织学和状态的不同而不同。在弥漫性淋巴细胞高分化淋巴瘤（DLWD）中，6项试验中只有1项受损，而在局限性DHL中，6项试验中有2项受损，在晚期DHL中，6项试验中有5项受损。结节性淋巴瘤患者IgA和IgG的平均水平降低，而弥漫性淋巴瘤患者只有IgA显著降低。尽管混合淋巴细胞培养与对照组没有显著差异，但所有组的丝裂原刺激均被抑制。恶性淋巴瘤患者的B细胞和T细胞免疫缺陷谱与组织学和分期相关。讨论了这些观察的意义和可能的机制。
Previously untreated patients (186) with malignant lymphoma were evaluated for immunocompetence by several tests of immune function; total circulating lymphocytes, T cells (E-rosettes), B cells (EAC-rosettes), delayed hypersensitivity to 6 recall antigens, serum Ig, mixed lymphocyte culture and lymphocyte mitogenic response to phytohemagglutinin and pokeweed mitogen. The results were correlated with histology, stage and clinical features. Diffuse lymphomas, especially diffuse histiocytic (large cell) (DHL), were associated with decreased absolute lymphocytes and E-rosette forming cells. Skin test reactivity varied with histology and state. Only 1 of 6 tests was impaired in diffuse lymphocytic well differentiated (DLWD) lymphoma in contrast to 2 of 6 in localized DHL and 5 of 6 in advanced DHL. Patients with nodular lymphoma exhibited depressed mean levels of IgA and IgG whereas only IgA was significantly decreased in diffuse lymphoma. Mitogen stimulation was depressed in all groups although mixed lymphocyte cultures did not differ significantly from controls. There is a spectrum of immunodeficiency of both B and T cell type in patients with malignant lymphoma that correlates with histology and stage. Implications and possible mechanisms of these observations are discussed.