Physiological and pathological roles of mitochondrial SLC25 carriers.
Physiological and pathological roles of mitochondrial SLC25 carriers.
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DOI：
10.1042/bj20121753
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发表时间：
2013-09-15
期刊：
影响因子：
--
通讯作者：
Baines CP
中科院分区：
文献类型：
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作者：
Gutiérrez-Aguilar M;Baines CP
线粒体依靠某些酶、离子和代谢物的区室化来实现有效的新陈代谢。为了实现其活性，无数载体在线粒体内膜中正确表达、靶向和折叠。在这些载体中，六跨膜螺旋线粒体 SLC25（溶质载体家族 25）蛋白促进具有不同化学特性的溶质穿过线粒体内膜的运输。尽管它们的正常功能补充了代谢反应所需的构建模块，但功能失调的 SLC25 蛋白与病理状态有关。本综述的目的是涵盖有关 SLC25 转运蛋白在健康和疾病中的作用的最新知识。
The mitochondrion relies on compartmentalization of certain enzymes, ions and metabolites for the sake of efficient metabolism. In order to fulfil its activities, a myriad of carriers are properly expressed, targeted and folded in the inner mitochondrial membrane. Among these carriers, the six-transmembrane-helix mitochondrial SLC25 (solute carrier family 25) proteins facilitate transport of solutes with disparate chemical identities across the inner mitochondrial membrane. Although their proper function replenishes building blocks needed for metabolic reactions, dysfunctional SLC25 proteins are involved in pathological states. It is the purpose of the present review to cover the current knowledge on the role of SLC25 transporters in health and disease.