Multislice brain myelin water fractions at 3T in multiple sclerosis
Multislice brain myelin water fractions at 3T in multiple sclerosis
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DOI：
10.1111/j.1552-6569.2007.00098.x
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发表时间：
2007-04-01
影响因子：
2.4
通讯作者：
Pelletier, Daniel
中科院分区：
文献类型：
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作者：
Oh, Joonmi;Han, Eric T.;Pelletier, Daniel
目的.旨在评价3 T下覆盖幕上脑的多层非线性间隔12回波成像序列，以定量多发性硬化（MS）患者的髓鞘水分数（MWF）。方法.研究了89例MS患者或有MS风险的患者（69例复发缓解型MS [RRMS]，7例继发性进展型MS [SPMS]，13例临床孤立综合征[CIS]）和28例对照。使用多层T2准备螺旋成像序列采集回波数据集，并使用非负最小二乘算法进行拟合。计算正常表现的白色物质（NAWM）、对比增强（CE）和非增强T2病变的平均MWF。结果对照组白色物质的平均MWF为11.3%。与对照组相比，MS患者NAWM的平均MWF显著降低（10.6%，P = .004）。病程> 5年的SPMS/RRMS患者（10.3%）的MWF低于病程> 5年的CIS/RRMS患者
Purpose. To evaluate a multislice nonlinearly-spaced 12-echo imaging sequence at 3T covering the supratentorial brain for the quantification of myelin water fraction (MWF) in multiple sclerosis (MS) patients. Methods. Eighty-nine patients with, or at risk of, MS (69 relapsing remitting MS [RRMS], 7 secondary progressive MS [SPMS], 13 clinically isolated syndrome [CIS]) and 28 controls were studied. Twelve-echo datasets were acquired using a multislice T2 prep spiral imaging sequence and were fitted using a nonnegative least squares algorithm. The mean MWF within normal appearing white matter (NAWM), contrast-enhancing (CE), and nonenhancing T2 lesions were calculated. Results. Mean MWF in white matter for controls was 11.3%. Mean MWF was significantly reduced in NAWM of MS patients (10.6%, P = .004) relative to controls. SPMS/RRMS patients with disease duration > 5 years (10.3%) had lower MWF compared to CIS/RRMS with disease duration