Nervous system effects of occupational manganese exposure on South African manganese mineworkers
Nervous system effects of occupational manganese exposure on South African manganese mineworkers
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DOI：
10.1016/s0161-813x(03)00035-4
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发表时间：
2003-08-01
期刊：
影响因子：
3.4
通讯作者：
Thompson, ML
中科院分区：
文献类型：
--
作者：
Myers, JE;teWaterNaude, J;Thompson, ML
职业接触空气中的锰尘已被证明会对中枢神经系统产生不利影响。对来自南非的489名蓝领和白领锰矿工人进行了横断面研究，以调查中至低职业锰暴露对神经系统的影响。不同的设施包括地下矿山、地面加工厂和办公地点。利用常规职业卫生数据构建工作暴露矩阵。暴露变量包括服务年限、所有工作的累积暴露指数（CEI）和平均暴露强度（AINT）以及血锰。终点包括Q16、WHO-NCTB、spe和Luria-Nebraska测试组的项目，以及简短的临床检查。潜在的混杂因素和影响因素包括年龄、教育水平、既往病史（包括以前的头部损伤）、以前接触神经毒性工作、吸烟、饮酒和家庭语言。通过多元线性和逻辑回归模型评估相关性。所有工作的平均暴露强度为0.21 mg/m(3)锰尘。多变量分析显示，在对混杂因素进行调整后，症状和测试结果都与包括血锰在内的任何暴露量无关。这项相对较大的零研究表明，锰矿工在所有工作中平均暴露于接近美国政府工业卫生学家会议阈值（ACGIH TLV）的二氧化锰水平，不太可能出现亚临床神经毒性问题。(C) 2003爱思唯尔科学有限公司版权所有
Occupational exposure to airborne manganese dust has been shown to produce adverse effects on the central nervous system. Four hundred and eighty-nine blue and white collar manganese mineworkers from South Africa were studied cross-sectionally to investigate the nervous system effects of medium to low occupational manganese exposures. The different facilities included underground mines, surface processing plants, and office locations. A job exposure matrix was constructed using routine occupational hygiene data. Exposure variables included years of service, a cumulative exposure index (CEI) and average intensity of exposure (AINT) across all jobs, and blood manganese. Endpoints included items from the Q16, WHO-NCTB, SPES, and Luria-Nebraska test batteries, and a brief clinical examination. Potential confounders and effect modifiers included age, level of education, past medical history including previous head injury, previous neurotoxic job exposures, tobacco use, alcohol use and home language. Associations were evaluated by multiple linear and logistic regression modeling. Average exposure intensity across all jobs was 0.21 mg/m(3) manganese dust. Multivariate analyses showed that none of the symptom nor test results were associated with any measure of exposure including blood manganese, after adjustment for confounders. This relatively large null study indicates that manganese miners exposed on average across all jobs to MnO2 at levels near the American Conference of Governmental Industrial Hygienists Threshold Limit Value (ACGIH TLV) are unlikely to have a subclinical neurotoxicity problem. (C) 2003 Elsevier Science Inc. All rights reserved