Bacterial sensing via neuronal Nod2 regulates appetite and body temperature
Bacterial sensing via neuronal Nod2 regulates appetite and body temperature
复制标题
DOI：
10.1126/science.abj3986
复制
发表时间：
2022-04-15
期刊：
影响因子：
56.9
通讯作者：
Lledo, Pierre-Marie
中科院分区：
文献类型：
--
作者：
Gabanyi, Ilana;Lepousez, Gabriel;Lledo, Pierre-Marie
Gut bacteria influence brain functions and metabolism. We investigated whether this influence can be mediated by direct sensing of bacterial cell wall components by brain neurons. In mice, we found that bacterial peptidoglycan plays a major role in mediating gut-brain communication via the Nod2 receptor. Peptidoglycan-derived muropeptides reach the brain and alter the activity of a subset of brain neurons that express Nod2. Activation of Nod2 in hypothalamic inhibitory neurons is essential for proper appetite and body temperature control, primarily in females. This study identifies a microbe-sensing mechanism that regulates feeding behavior and host metabolism.
